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Tchem
RIPK4
Receptor-interacting serine/threonine-protein kinase 4

Protein Summary
Description
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332512
  • ENSP00000332454
  • ENSG00000183421
  • ENST00000352483
  • ENSP00000330161

Symbol
  • ANKRD3
  • DIK
  • DIK
  • PKK
  • PPS2
  • RIP4
  • ANKK2
  • NKRD3
  • ANKRD3
  • CHANDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.78
virus perturbation
0.68
gene perturbation
0.67
transcription factor binding site profile
0.67
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.65   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.65   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (87)
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999990302
p_ni:  0.000009698
Score:  0.236
Data Source:  BioPlex,STRINGDB
SPATA5L1
Tdark
Family:  Enzyme
Novelty:  0.5393372
p_int:  0.999988651
p_ni:  0.000011335
p_wrong:  1.4e-8
Score:  0.292
Data Source:  BioPlex,STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999841692
p_ni:  0.000158308
Data Source:  BioPlex
PID1
Tbio
Novelty:  0.01949514
p_int:  0.997750286
p_ni:  0.002094156
p_wrong:  0.000155558
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.986172484
p_ni:  0.013820073
p_wrong:  0.000007444
Data Source:  BioPlex
ENPP6
Tbio
Family:  Enzyme
Novelty:  0.06933544
p_int:  0.984391631
p_ni:  0.015606912
p_wrong:  0.000001457
Score:  0.18
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.971593378
p_ni:  0.007095042
p_wrong:  0.02131158
Data Source:  BioPlex
AGT
Tbio
Novelty:  0.00049613
p_int:  0.968270485
p_ni:  0.029067675
p_wrong:  0.002661841
Score:  0.209
Data Source:  BioPlex,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.961648176
p_ni:  0.037091852
p_wrong:  0.001259972
Data Source:  BioPlex
AVIL
Tbio
Novelty:  0.0175973
p_int:  0.959287208
p_ni:  0.028834041
p_wrong:  0.011878751
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (172)
Find Similar Targets
Items per page:
1 – 5 of 172
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Pancreatic adenocarcinoma pathway
WikiPathways
Pancreatic adenocarcinoma pathway
WikiPathways
Pancreatic adenocarcinoma pathway
WikiPathways
Pancreatic adenocarcinoma pathway
WikiPathways
Pancreatic adenocarcinoma pathway
Name
Explore in Pharos
Explore in Source
Pancreatic adenocarcinoma pathway
Pancreatic adenocarcinoma pathway
Pancreatic adenocarcinoma pathway
Pancreatic adenocarcinoma pathway
Pancreatic adenocarcinoma pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
1
1.1
78.5
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
1
0
2.4
27.3
insomnia measurement
1
1
0
1.1
21.5
keratinocyte carcinoma
1
1
0
1.1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
78.5
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
2.4
27.3
insomnia measurement
0
1.1
21.5
keratinocyte carcinoma
0
1.1
21.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor interacting serine/threonine kinase 4
VGNC:6593
470094
Macaque
receptor interacting serine/threonine kinase 4
715077
Mouse
MGI:1919638
72388
Rat
RGD:1311691
304053
Dog
receptor interacting serine/threonine kinase 4
VGNC:45596
487772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor interacting serine/threonine kinase 4
Macaque
receptor interacting serine/threonine kinase 4
Mouse
Rat
Dog
receptor interacting serine/threonine kinase 4
Publication Statistics
PubMed Score 139.65
PubMed score by year
PubTator Score 35.08
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title