Tbio UBASH3A Ubiquitin-associated and SH3 domain-containing protein A

Protein Summary

Description

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P57075
• G5E9E4
• Q6HA34
• Q6HA35
• Q6ISI6
• Q6ISK3
• Q6ISS9

Gene Name

• UBASH3A

Ensembl ID

• ENST00000291535
• ENSP00000291535
• ENSG00000160185
• ENST00000319294
• ENSP00000317327
• ENST00000398367
• ENSP00000381408

Symbol

• STS2
• TULA
• CLIP4
• STS-2
• TULA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
protein domain	0.85
tissue sample	0.73
phenotype	0.65
disease	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.97   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.97   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0