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Tbio
SOX8
Transcription factor SOX-8

Protein Summary
Description
May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293894
  • ENSP00000293894
  • ENSG00000005513
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.79
gene perturbation
0.65
transcription factor
0.65
tissue sample
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.8   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.8   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 8
VGNC:5922
453811
Mouse
MGI:98370
20681
Rat
RGD:1309072
302993
Dog
SRY-box 8
VGNC:46683
490082
Horse
SRY-box 8
VGNC:23464
100067353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 8
Mouse
Rat
Dog
SRY-box 8
Horse
SRY-box 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P57073-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
Name
Explore in Pharos
Explore in Source
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Gene Ontology Terms (44)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (67)
1 – 10 of 67
FOXL2
Tbio
Family: TF
Novelty: 0.00224046
Score: 0.763
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.0015221
Score: 0.719
Data Source: STRINGDB
NR5A1
Tchem
Family: NR
Novelty: 0.00126037
Score: 0.679
Data Source: STRINGDB
AMH
Tbio
Novelty: 0.00022501
Score: 0.665
Data Source: STRINGDB
LATS2
Tchem
Family: Kinase
Novelty: 0.00521035
Score: 0.632
Data Source: STRINGDB
PAX3
Tbio
Family: TF
Novelty: 0.00140464
Score: 0.632
Data Source: STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.00808235
Score: 0.628
Data Source: STRINGDB
DMRT1
Tbio
Family: TF
Novelty: 0.00403133
Score: 0.617
Data Source: STRINGDB
OLIG1
Tbio
Family: TF
Novelty: 0.01006324
Score: 0.606
Data Source: STRINGDB
POU3F3
Tbio
Family: TF
Novelty: 0.00954977
Score: 0.603
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.80

PubMed score by year
PubTator Score  23.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer