You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SOX8
Transcription factor SOX-8

Protein Summary
Description
May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity). This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293894
  • ENSP00000293894
  • ENSG00000005513
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.79
gene perturbation
0.65
transcription factor
0.65
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (9)
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
Name
Explore in Pharos
Explore in Source
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Gene Ontology Terms (44)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (67)
1 – 10 of 67
FOXL2
Tbio
Family: TF
Novelty: 0.00136796
Score: 0.763
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.00211969
Score: 0.719
Data Source: STRINGDB
NR5A1
Tchem
Family: NR
Novelty: 0.00114781
Score: 0.679
Data Source: STRINGDB
AMH
Tbio
Novelty: 0.0003157
Score: 0.665
Data Source: STRINGDB
LATS2
Tchem
Family: Kinase
Novelty: 0.00277994
Score: 0.632
Data Source: STRINGDB
PAX3
Tbio
Family: TF
Novelty: 0.00139998
Score: 0.632
Data Source: STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.01178113
Score: 0.628
Data Source: STRINGDB
DMRT1
Tbio
Family: TF
Novelty: 0.00466598
Score: 0.617
Data Source: STRINGDB
OLIG1
Tbio
Family: TF
Novelty: 0.01364441
Score: 0.606
Data Source: STRINGDB
POU3F3
Tbio
Family: TF
Novelty: 0.00618015
Score: 0.603
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.14

PubMed score by year
PubTator Score  23.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAADERFPACIRD
1-70
AVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLW
70-140
RLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAKAGHSDSDSGAELGPHPGGGAVYKAEAGLGD
140-210
GHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAF
210-280
DVHEFDQYLPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGD
280-350
QPRGSPDYGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLL
350-420
NGLALPPAHSPTSHWDQPVYTTLTRP
420-446
MLDMSEARSQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGRAGVAVGGARGDPAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGALKAKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKSAKAGHSDSDSGAELGPHPGGGAVYKAEAGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELSSEVMGTMDAFDVHEFDQYLPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPTETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGPFAGSQGDYGDLQASSYYGAYPGYAPGLYQYPCFHSPRRPYASPLLNGLALPPAHSPTSHWDQPVYTTLTRP