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Tbio
PRDM15
PR domain zinc finger protein 15

Protein Summary
Description
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269844
  • ENSP00000269844
  • ENSG00000141956
  • ENST00000398548
  • ENSP00000381556
  • ENST00000422911
  • ENSP00000408592
  • ENST00000433067
  • ENSP00000415471
  • ENST00000449395
  • ENSP00000396943

Symbol
  • C21orf83
  • ZNF298
  • PFM15
  • ZNF298
  • C21orf83
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
histone modification site profile
0.67
phenotype
0.65
cell line
0.61
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.985571426
p_ni:  0.014428569
p_wrong:  6e-9
Data Source:  BioPlex
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.984298113
p_ni:  0.01570187
p_wrong:  1.7e-8
Data Source:  BioPlex
RNF151
Tdark
Novelty:  2.0077961
p_int:  0.952666525
p_ni:  0.047326148
p_wrong:  0.000007327
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.94396401
p_ni:  0.05603599
Data Source:  BioPlex
PRR11
Tbio
Novelty:  0.05077483
p_int:  0.943109249
p_ni:  0.056890751
Score:  0.517
Data Source:  BioPlex,STRINGDB
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.915371722
p_ni:  0.084628278
Score:  0.33
Data Source:  BioPlex,STRINGDB
ZNF490
Tdark
Family:  TF
Novelty:  2.7619637
p_int:  0.895366594
p_ni:  0.104633035
p_wrong:  3.72e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
GNL3
Tbio
Novelty:  0.00886703
p_int:  0.833776591
p_ni:  0.164596509
p_wrong:  0.0016269
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.831798586
p_ni:  0.168201412
p_wrong:  2e-9
Data Source:  BioPlex
RPL7A
Tbio
Novelty:  0.01674027
p_int:  0.824301672
p_ni:  0.091251164
p_wrong:  0.084447164
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
FOXA1 transcription factor network
PathwayCommons: pid
Validated nuclear estrogen receptor alpha network
Name
Explore in Pharos
Explore in Source
FOXA1 transcription factor network
Validated nuclear estrogen receptor alpha network
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
52.4
testosterone measurement
2
1
2
48.5
platelet count
1
1
1
46.5
a disintegrin and metalloproteinase with thrombospondin motifs 13
1
1
0
2.4
27.3
insomnia measurement
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
52.4
testosterone measurement
2
48.5
platelet count
1
46.5
a disintegrin and metalloproteinase with thrombospondin motifs 13
0
2.4
27.3
insomnia measurement
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1930121
114604
Rat
RGD:1310055
304054
Dog
PR/SET domain 15
VGNC:44947
610905
Horse
PR/SET domain 15
100058322
Cow
PR/SET domain 15
VGNC:33293
514566
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
PR/SET domain 15
Horse
PR/SET domain 15
Cow
PR/SET domain 15
Publication Statistics
PubMed Score 6.95
PubMed score by year
PubTator Score 3.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title