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Tchem
SIK1
Serine/threonine-protein kinase SIK1

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270162
  • ENSP00000270162
  • ENSG00000142178

Symbol
  • SIK
  • SNF1LK
  • MSK
  • SIK
  • SIK-1
  • SIK1B
  • SNF1LK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.8
transcription factor perturbation
0.74
transcription factor binding site profile
0.73
small molecule
0.68
disease
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.88   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.88   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (58)
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999969488
p_ni:  0.000030502
p_wrong:  1e-8
Score:  0.345
Data Source:  BioPlex,STRINGDB
SIK2
Tchem
Family:  Kinase
Novelty:  0.01957886
p_int:  0.999914533
p_ni:  0.000080763
p_wrong:  0.000004704
Score:  0.388
Data Source:  BioPlex,STRINGDB
GINS4
Tbio
Novelty:  0.0316194
p_int:  0.999490659
p_ni:  0.000509341
Score:  0.264
Data Source:  BioPlex,STRINGDB
UBE2E1
Tbio
Novelty:  0.04048768
p_int:  0.910832624
p_ni:  0.089043407
p_wrong:  0.00012397
Score:  0.197
Data Source:  BioPlex,STRINGDB
SIK3
Tchem
Family:  Kinase
Novelty:  0.02936655
p_int:  0.757302989
p_ni:  0.000333229
p_wrong:  0.242363782
Score:  0.494
Data Source:  BioPlex,STRINGDB
CRTC2
Tbio
Novelty:  0.01888215
Score:  0.969
Data Source:  STRINGDB
STK11
Tchem
Family:  Kinase
Novelty:  0.00073247
Score:  0.954
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.937
Data Source:  STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.926
Data Source:  STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
Score:  0.926
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
2
0
1.1
66
1
1
0
1.1
24.5
diastolic blood pressure
2
1
2
10.5
Agents acting on the renin-angiotensin system use measurement
1
1
1
5.4
fertility measurement
1
1
0
3.8
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
66
0
1.1
24.5
diastolic blood pressure
2
10.5
Agents acting on the renin-angiotensin system use measurement
1
5.4
fertility measurement
0
3.8
2.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
salt inducible kinase 1
474029
Macaque
salt inducible kinase 1
722303
Mouse
MGI:104754
17691
Rat
RGD:69407
59329
Dog
salt inducible kinase 1
487787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
salt inducible kinase 1
Macaque
salt inducible kinase 1
Mouse
Rat
Dog
salt inducible kinase 1
Publication Statistics
PubMed Score 202.88
PubMed score by year
PubTator Score 94.54
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title