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Tchem
SIK1
Serine/threonine-protein kinase SIK1

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling (PubMed:29211348). Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270162
  • ENSP00000270162
  • ENSG00000142178

Symbol
  • SIK
  • SNF1LK
  • MSK
  • SIK
  • SIK-1
  • SIK1B
  • SNF1LK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.8
transcription factor perturbation
0.74
transcription factor binding site profile
0.73
small molecule
0.68
disease
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 762.66   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 762.66   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
dasatinib
chemical structure image
bosutinib
chemical structure image
Pathways (136)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
Circadian Clock
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (58)
1 – 10 of 58
GINS2
Tbio
Novelty: 0.0122257
p_int: 0.999969488
p_ni: 0.000030502
p_wrong: 1e-8
Score: 0.345
Data Source: BioPlex,STRINGDB
SIK2
Tchem
Family: Kinase
Novelty: 0.02679057
p_int: 0.999914533
p_ni: 0.000080763
p_wrong: 0.000004704
Score: 0.388
Data Source: BioPlex,STRINGDB
GINS4
Tbio
Novelty: 0.04568785
p_int: 0.999490659
p_ni: 0.000509341
Score: 0.264
Data Source: BioPlex,STRINGDB
UBE2E1
Tbio
Novelty: 0.05570885
p_int: 0.910832624
p_ni: 0.089043407
p_wrong: 0.00012397
Score: 0.197
Data Source: BioPlex,STRINGDB
SIK3
Tchem
Family: Kinase
Novelty: 0.04907412
p_int: 0.757302989
p_ni: 0.000333229
p_wrong: 0.242363782
Score: 0.494
Data Source: BioPlex,STRINGDB
CRTC2
Tbio
Novelty: 0.02665733
Score: 0.969
Data Source: STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00094968
Score: 0.954
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.937
Data Source: STRINGDB
YWHAE
Tbio
Novelty: 0.00548639
Score: 0.926
Data Source: STRINGDB
YWHAZ
Tbio
Novelty: 0.00235606
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  762.66

PubMed score by year
PubTator Score  94.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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