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Tdark
RIPPLY3
Protein ripply3

Protein Summary
Description
Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329553
  • ENSP00000331734
  • ENSG00000183145

Symbol
  • DSCR6
  • DSCR6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell type or tissue
0.76
phenotype
0.69
histone modification site profile
0.65
biological process
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye color
1
1
1
42.3
birth weight
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eye color
1
42.3
birth weight
1
4.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ripply transcriptional repressor 3
VGNC:1129
747361
Mouse
MGI:2181192
170765
Rat
RGD:1308788
288239
Dog
ripply transcriptional repressor 3
VGNC:53037
100688594
Horse
ripply transcriptional repressor 3
VGNC:22404
100630857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ripply transcriptional repressor 3
Mouse
Rat
Dog
ripply transcriptional repressor 3
Horse
ripply transcriptional repressor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P57055-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (21)
1 – 10 of 21
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.999955925
p_ni:  5.3e-8
p_wrong:  0.000044021
Data Source:  BioPlex
TIFA
Tbio
Novelty:  0.077012
Score:  0.732
Data Source:  STRINGDB
SH3BGR
Tbio
Novelty:  0.19912265
Score:  0.696
Data Source:  STRINGDB
PSMG1
Tbio
Novelty:  0.08175356
Score:  0.695
Data Source:  STRINGDB
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
Score:  0.68
Data Source:  STRINGDB
DSCR3
Tbio
Novelty:  0.05414856
Score:  0.646
Data Source:  STRINGDB
KCNJ6
Tchem
Family:  IC
Novelty:  0.00330353
Score:  0.645
Data Source:  STRINGDB
DSCR4
Tdark
Novelty:  0.06035045
Score:  0.64
Data Source:  STRINGDB
ZNF214
Tbio
Family:  TF
Novelty:  0.15323721
Score:  0.635
Data Source:  STRINGDB
PIGP
Tbio
Family:  Enzyme
Novelty:  0.01400934
Score:  0.598
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.72

PubMed score by year
PubTator Score  2.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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