Tbio PIGP Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

Protein Summary

Description

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P57054
• A0A0C4DH71
• B2RB18
• B2RE99
• B5BU92
• D3DSG7
• J3KR75
• Q53Y28
• Q96KI1
• Q9NZA6

Gene Name

• PIGP

Ensembl ID

• ENST00000360525
• ENSP00000353719
• ENSG00000185808
• ENST00000399098
• ENSP00000382049
• ENST00000399102
• ENSP00000382053
• ENST00000399103
• ENSP00000382054
• ENST00000464265
• ENSP00000420037

Symbol

• DCRC
• DSCR5
• DSCRC
• DCRC
• DSRC
• DSCR5
• PIG-P
• DCRC-S
• EIEE55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
virus perturbation	0.85
transcription factor binding site profile	0.82
cell type or tissue	0.78
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.53   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.53   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0