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Tbio
H2BFS
Histone H2B type F-S

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000599962
  • ENSP00000481622
  • ENSG00000234289
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.98
interacting protein
0.86
small molecule perturbation
0.65
tissue
0.65
cellular component
0.5


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.56   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.56   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (80)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 80
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (376)
1 – 10 of 376
HIST1H2AC
Tdark
Novelty: 0.4785744
Score: 0.988
Data Source: STRINGDB
H2AFV
Tbio
Novelty: 0.03561635
Score: 0.985
Data Source: STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
Score: 0.983
Data Source: STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
Score: 0.982
Data Source: STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.972
Data Source: STRINGDB
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.962
Data Source: STRINGDB
H2AFB1
Tbio
Novelty: 0.08770329
Score: 0.959
Data Source: STRINGDB
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.957
Data Source: STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.956
Data Source: STRINGDB
HIST1H2BK
Tbio
Novelty: 0.12867647
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.56

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer