Tbio RBM11 Splicing regulator RBM11

Protein Summary

Description

Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1.

Uniprot Accession IDs

• P57052
• Q6YNC2
• Q8NBA1
• Q8NFF6

Gene Name

• RBM11

Ensembl ID

• ENST00000400577
• ENSP00000383421
• ENSG00000185272

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.74
gene perturbation	0.71
virus perturbation	0.68
tissue sample	0.65
molecular function	0.56

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Splicing Regulator Rbm11

DTO Classes

Protein / Nucleic Acid Binding / Splicing Regulator Rbm11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0