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Tbio
STX17
Syntaxin-17

Protein Summary
Description
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259400
  • ENSP00000259400
  • ENSG00000136874
  • ENST00000525640
  • ENSP00000435981
  • ENST00000534052
  • ENSP00000433484
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.94
cellular component
0.91
interacting protein
0.85
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.32   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.32   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.8983667
p_ni:  0.101632135
p_wrong:  0.000001165
Score:  0.158
Data Source:  BioPlex,STRINGDB
TMCO3
Tdark
Novelty:  1.16719823
p_int:  0.859386227
p_ni:  0.140613773
Score:  0.198
Data Source:  BioPlex,STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
Score:  0.999
Data Source:  STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
Score:  0.999
Data Source:  STRINGDB
VAMP7
Tbio
Novelty:  0.00900603
Score:  0.984
Data Source:  STRINGDB
STX5
Tbio
Novelty:  0.00964918
Score:  0.983
Data Source:  STRINGDB
NSF
Tbio
Family:  Enzyme
Novelty:  0.00173489
Score:  0.98
Data Source:  STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.98
Data Source:  STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
Score:  0.974
Data Source:  STRINGDB
NAPA
Tbio
Novelty:  0.00618772
Score:  0.972
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
32.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 17
VGNC:4870
472994
Macaque
syntaxin 17
714699
Mouse
MGI:1914977
67727
Rat
RGD:708499
252853
Dog
syntaxin 17
VGNC:46951
481630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 17
Macaque
syntaxin 17
Mouse
Rat
Dog
syntaxin 17
Publication Statistics
PubMed Score 83.32
PubMed score by year
PubTator Score 27.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title