You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STX17
Syntaxin-17

Protein Summary
Description
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane (PubMed:23217709, PubMed:25686604). May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259400
  • ENSP00000259400
  • ENSG00000136874
  • ENST00000525640
  • ENSP00000435981
  • ENST00000534052
  • ENSP00000433484
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.94
cellular component
0.91
interacting protein
0.85
histone modification site profile
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.71   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.71   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 17
VGNC:4870
472994
Macaque
syntaxin 17
714699
Mouse
MGI:1914977
67727
Rat
RGD:708499
252853
Dog
syntaxin 17
VGNC:46951
481630
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 17
Macaque
syntaxin 17
Mouse
Rat
Dog
syntaxin 17
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56962-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (27)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (188)
1 – 10 of 188
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.8983667
p_ni: 0.101632135
p_wrong: 0.000001165
Score: 0.158
Data Source: BioPlex,STRINGDB
TMCO3
Tdark
Novelty: 1.16719823
p_int: 0.859386227
p_ni: 0.140613773
Score: 0.198
Data Source: BioPlex,STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
Score: 0.999
Data Source: STRINGDB
SNAP29
Tbio
Novelty: 0.02009206
Score: 0.999
Data Source: STRINGDB
VAMP7
Tbio
Novelty: 0.00900603
Score: 0.984
Data Source: STRINGDB
STX5
Tbio
Novelty: 0.00964918
Score: 0.983
Data Source: STRINGDB
NSF
Tbio
Family: Enzyme
Novelty: 0.00173489
Score: 0.98
Data Source: STRINGDB
YKT6
Tbio
Novelty: 0.01591063
Score: 0.98
Data Source: STRINGDB
SEC22B
Tbio
Novelty: 0.03035448
Score: 0.974
Data Source: STRINGDB
NAPA
Tbio
Novelty: 0.00618772
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.71

PubMed score by year
PubTator Score  27.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer