Tbio BCAR1 Breast cancer anti-estrogen resistance protein 1

Protein Summary

Description

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017]

Uniprot Accession IDs

• P56945
• B3KWD7
• B4DEV4
• B4DGB5
• B4DIW5
• B7Z7X7
• E9PCL5
• E9PCV2
• F5GXA2
• F5GXV6
• F5H7Z0
• F8WA69
• Q6QEF7

Gene Name

• BCAR1

Ensembl ID

• ENST00000162330
• ENSP00000162330
• ENSG00000050820
• ENST00000393420
• ENSP00000377072
• ENST00000393422
• ENSP00000377074
• ENST00000418647
• ENSP00000391669
• ENST00000420641
• ENSP00000392708
• ENST00000535626
• ENSP00000440370
• ENST00000538440
• ENSP00000443841
• ENST00000542031
• ENSP00000440415

Symbol

• CAS
• CASS1
• CRKAS
• CAS
• CAS1
• CASS1
• CRKAS
• P130Cas

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
hub protein	0.98
phosphatase	0.9
biological term	0.86
cellular component	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.84   (req: < 5)

Gene RIFs: 102   (req: <= 3)

Antibodies: 720   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.84   (req: >= 5)

Gene RIFs: 102   (req: > 3)

Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0