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Tbio
BCAR1
Breast cancer anti-estrogen resistance protein 1

Protein Summary
Description
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000162330
  • ENSP00000162330
  • ENSG00000050820
  • ENST00000393420
  • ENSP00000377072
  • ENST00000393422
  • ENSP00000377074
  • ENST00000418647
  • ENSP00000391669
  • ENST00000420641
  • ENSP00000392708
  • ENST00000535626
  • ENSP00000440370
  • ENST00000538440
  • ENSP00000443841
  • ENST00000542031
  • ENSP00000440415

Symbol
  • CAS
  • CASS1
  • CRKAS
  • CAS
  • CAS1
  • CASS1
  • CRKAS
  • P130Cas
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
hub protein
0.98
phosphatase
0.9
biological term
0.86
cellular component
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.47   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 258.47   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.4
63.6
1
1
1
7.6
parental genotype effect measurement
1
1
1
3.2
birth weight
1
1
1
3.2
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
63.6
1
7.6
parental genotype effect measurement
1
3.2
birth weight
1
3.2
1
2.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCAR1, Cas family scaffold protein
VGNC:10129
454246
Macaque
BCAR1, Cas family scaffolding protein
713965
Mouse
MGI:108091
12927
Rat
RGD:2406
25414
Dog
BCAR1, Cas family scaffold protein
VGNC:38398
479648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCAR1, Cas family scaffold protein
Macaque
BCAR1, Cas family scaffolding protein
Mouse
Rat
Dog
BCAR1, Cas family scaffold protein
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56945-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (57)
Downstream signal transduction (R-HSA-186763)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downstream signal transduction
Reactome
Hemostasis
Reactome
Integrin alphaIIb beta3 signaling
Reactome
Integrin signaling
Reactome
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Name
Explore in Pharos
Explore in Source
Downstream signal transduction
Hemostasis
Integrin alphaIIb beta3 signaling
Integrin signaling
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Gene Ontology Terms (31)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (255)
1 – 10 of 255
BCAR3
Tbio
Novelty: 0.05420404
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
PXN
Tbio
Novelty: 0.00082031
Score: 0.999
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.996
Data Source: Reactome,STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.996
Data Source: Reactome,STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.995
Data Source: Reactome,STRINGDB
PTK2B
Tclin
Family: Kinase
Novelty: 0.00174314
Score: 0.992
Data Source: STRINGDB
CRKL
Tbio
Novelty: 0.0051181
Score: 0.989
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.989
Data Source: STRINGDB
DOCK1
Tbio
Novelty: 0.00867391
Score: 0.988
Data Source: Reactome,STRINGDB
VCL
Tbio
Novelty: 0.00043107
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  258.47

PubMed score by year
PubTator Score  733.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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