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Tbio
GSC
Homeobox protein goosecoid

Protein Summary
Description
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity). Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238558
  • ENSP00000238558
  • ENSG00000133937

Symbol
  • SAMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.63
gene perturbation
0.58
transcription factor binding site profile
0.58
biological process
0.57
cell line
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.98   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.98   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.948984044
p_ni:  0.051015956
Score:  0.226
Data Source:  BioPlex,STRINGDB
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.889508588
p_ni:  0.110415474
p_wrong:  0.000075938
Score:  0.188
Data Source:  BioPlex,STRINGDB
E2F1
Tbio
Family:  TF
Novelty:  0.00277137
Score:  0.902
Data Source:  STRINGDB
E2F3
Tbio
Family:  TF
Novelty:  0.00287552
Score:  0.902
Data Source:  STRINGDB
E2F2
Tbio
Family:  TF
Novelty:  0.00418995
Score:  0.902
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.9
Data Source:  STRINGDB
TFDP1
Tbio
Family:  TF
Novelty:  0.02026858
Score:  0.9
Data Source:  STRINGDB
RB1
Tchem
Novelty:  0.00063798
Score:  0.9
Data Source:  STRINGDB
TBXT
Tbio
Family:  TF
Novelty:  0.00660122
Score:  0.73
Data Source:  STRINGDB
CHRD
Tbio
Novelty:  0.00347659
Score:  0.631
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
20.9
1
1
1
3.8
nose morphology measurement
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
20.9
1
3.8
nose morphology measurement
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
goosecoid homeobox
VGNC:3412
467546
Mouse
MGI:95841
14836
Rat
RGD:631425
317715
Dog
goosecoid homeobox
VGNC:41525
100683589
Cow
goosecoid homeobox
VGNC:29672
514862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
goosecoid homeobox
Mouse
Rat
Dog
goosecoid homeobox
Cow
goosecoid homeobox
Publication Statistics
PubMed Score 5.98
PubMed score by year
PubTator Score 17.14
PubTator score by year
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Related Publications
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0 of 0
PMID
Text