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Tbio
CLDN18
Claudin-18

Protein Summary
Description
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000183605
  • ENSP00000183605
  • ENSG00000066405
  • ENST00000343735
  • ENSP00000340939

Symbol
  • SFTA5
  • SFTPJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.66
tissue sample
0.66
cell type or tissue
0.63
protein domain
0.58
virus perturbation
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.04   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.04   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
claudin 18
VGNC:1783
470935
Macaque
claudin 18
716628
Mouse
MGI:1929209
56492
Rat
RGD:1359696
315953
Dog
claudin 18
VGNC:39314
477079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
claudin 18
Macaque
claudin 18
Mouse
Rat
Dog
claudin 18
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56856-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (50)
Cell junction organization (R-HSA-446728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Tight junction interactions
Name
Explore in Pharos
Explore in Source
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Tight junction interactions
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (61)
1 – 10 of 61
THEM4
Tbio
Family: Enzyme
Novelty: 0.0191855
p_int: 0.942753534
p_ni: 0.05678743
p_wrong: 0.000459036
Score: 0.332
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.928866943
p_ni: 0.071133057
Data Source: BioPlex
CLDN12
Tbio
Novelty: 0.04404633
Score: 0.957
Data Source: STRINGDB
CLDN23
Tbio
Novelty: 0.12349944
Score: 0.95
Data Source: STRINGDB
CLDN19
Tbio
Novelty: 0.02391772
Score: 0.939
Data Source: STRINGDB
CLDN10
Tbio
Novelty: 0.02175843
Score: 0.934
Data Source: STRINGDB
CLDN16
Tbio
Novelty: 0.0092505
Score: 0.919
Data Source: STRINGDB
CLDN5
Tbio
Novelty: 0.00174396
Score: 0.918
Data Source: STRINGDB
CLDN2
Tbio
Novelty: 0.00299455
Score: 0.914
Data Source: STRINGDB
CLDN11
Tbio
Novelty: 0.00275436
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  90.04

PubMed score by year
PubTator Score  45.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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