Protein Summary
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type. This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
- ENST00000313005
- ENSP00000318585
- ENSG00000186318
- ENST00000392937
- ENSP00000475405
- ENST00000428381
- ENSP00000402228
- ENST00000445823
- ENSP00000403685
- ENST00000510630
- ENSP00000422461
- ENST00000513780
- ENSP00000424536
- BACE
- KIAA1149
- ASP2
- BACE
- HSPC104
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.97 | ||
drug | 0.93 | ||
virus perturbation | 0.88 | ||
microRNA | 0.83 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2642.42 (req: < 5)
Gene RIFs: 310 (req: <= 3)
Antibodies: 845 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2642.42 (req: >= 5)
Gene RIFs: 310 (req: > 3)
Antibodies: 845 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5415
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (5415)
Protein-Protein Interactions (194)
SCGB1D4
Novelty: 0.15597658
p_int: 0.996425702
p_ni: 0.001137923
p_wrong: 0.002436375
Score: 0.369
Data Source: BioPlex,STRINGDB
SCGB2A1
Novelty: 0.01902973
p_int: 0.770605629
p_ni: 0.000096222
p_wrong: 0.229298149
Data Source: BioPlex
Nearest Tclin Targets
Pathways (32)
Reactome (2)
KEGG (1)
PathwayCommons (2)
WikiPathways (27)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (6)
Components (23)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Physical Interaction (IPI) | Alzheimers_University_of_Toronto | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 7 | 14 | 21 | 99.8 | |||||
apolipoprotein A 1 measurement | 2 | 8 | 8 | 98.4 | |||||
total cholesterol measurement | 2 | 5 | 6 | 94.6 | |||||
high density lipoprotein cholesterol measurement | 7 | 10 | 12 | 17 | 94.2 | ||||
apolipoprotein B measurement | 2 | 5 | 5 | 90.8 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 21 | 99.8 | |||||
apolipoprotein A 1 measurement | 8 | 98.4 | |||||
total cholesterol measurement | 6 | 94.6 | |||||
high density lipoprotein cholesterol measurement | 12 | 17 | 94.2 | ||||
apolipoprotein B measurement | 5 | 90.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | beta-secretase 1 | VGNC:10433 | 451573 | |||||
Macaque | beta-secretase 1 | 697694 | ||||||
Mouse | MGI:1346542 | 23821 | ||||||
Rat | RGD:2191 | 29392 | ||||||
Dog | beta-secretase 1 | VGNC:38358 | 489390 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | beta-secretase 1 | |||||
Macaque | beta-secretase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | beta-secretase 1 | |||||
Publication Statistics
PubMed Score 2642.42
PubMed score by year
PubTator Score 1207.61
PubTator score by year
Related Publications
Text Mined References (353)
GeneRif Annotations (310)
Items per page:
0 of 0
PMID | Year | Title |
|---|