Tchem BACE1 Beta-secretase 1

Protein Summary

Description

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type. This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P56817
• A0M8W7
• B0YIU9
• E9PE65
• H7BXJ9
• Q9BYB9
• Q9BYC0
• Q9BYC1
• Q9UJT5
• Q9ULS1

Gene Name

• BACE1

Ensembl ID

• ENST00000313005
• ENSP00000318585
• ENSG00000186318
• ENST00000392937
• ENSP00000475405
• ENST00000428381
• ENSP00000402228
• ENST00000445823
• ENSP00000403685
• ENST00000510630
• ENSP00000422461
• ENST00000513780
• ENSP00000424536

Symbol

• BACE
• KIAA1149
• ASP2
• BACE
• HSPC104

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.97
drug	0.93
virus perturbation	0.88
microRNA	0.83
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Aspartic Protease / Beta-secretase 1

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Beta-secretase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3178.78   (req: < 5)

Gene RIFs: 369   (req: <= 3)

Antibodies: 845   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3178.78   (req: >= 5)

Gene RIFs: 369   (req: > 3)

Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5472

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1