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Tchem
BACE1
Beta-secretase 1

Protein Summary
Description
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. Cleaves APP with much more catalytic efficiency than for the wild-type. This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313005
  • ENSP00000318585
  • ENSG00000186318
  • ENST00000392937
  • ENSP00000475405
  • ENST00000428381
  • ENSP00000402228
  • ENST00000445823
  • ENSP00000403685
  • ENST00000510630
  • ENSP00000422461
  • ENST00000513780
  • ENSP00000424536

Symbol
  • BACE
  • KIAA1149
  • ASP2
  • BACE
  • HSPC104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.97
drug
0.93
virus perturbation
0.88
microRNA
0.83
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2554.55   (req: < 5)
Gene RIFs: 310   (req: <= 3)
Antibodies: 845   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2554.55   (req: >= 5)
Gene RIFs: 310   (req: > 3)
Antibodies: 845   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4952
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
80.6
apolipoprotein A 1 measurement
1
1
1
60.6
high density lipoprotein cholesterol measurement
1
1
1
54.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
80.6
apolipoprotein A 1 measurement
1
60.6
high density lipoprotein cholesterol measurement
1
54.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-secretase 1
VGNC:10433
451573
Macaque
beta-secretase 1
697694
Mouse
MGI:1346542
23821
Rat
RGD:2191
29392
Dog
beta-secretase 1
VGNC:38358
489390
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-secretase 1
Macaque
beta-secretase 1
Mouse
Rat
Dog
beta-secretase 1
Protein Structure (373 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56817-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 373
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Gene Ontology Terms (43)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
Alzheimers_University_of_Toronto
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (194)
1 – 10 of 194
SCGB1D4
Tdark
Novelty: 0.15597658
p_int: 0.996425702
p_ni: 0.001137923
p_wrong: 0.002436375
Score: 0.369
Data Source: BioPlex,STRINGDB
SCGB2A1
Tbio
Novelty: 0.01902973
p_int: 0.770605629
p_ni: 0.000096222
p_wrong: 0.229298149
Data Source: BioPlex
APP
Tchem
Novelty: 0.00008964
Score: 0.997
Data Source: Reactome,STRINGDB
GGA1
Tbio
Novelty: 0.00866392
Score: 0.985
Data Source: Reactome,STRINGDB
GGA3
Tbio
Novelty: 0.01898553
Score: 0.983
Data Source: Reactome,STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.972
Data Source: STRINGDB
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00024189
Score: 0.958
Data Source: STRINGDB
GGA2
Tbio
Novelty: 0.01750948
Score: 0.958
Data Source: Reactome,STRINGDB
LRP1
Tbio
Novelty: 0.00200788
Score: 0.928
Data Source: STRINGDB
NCSTN
Tbio
Novelty: 0.00453935
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  2554.55

PubMed score by year
PubTator Score  1207.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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