Protein Summary
Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an i ...more
- ENST00000399899
- ENSP00000382783
- ENSG00000156284
- HEL-S-79
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.92 | ||
microRNA | 0.66 | ||
protein domain | 0.58 | ||
tissue sample | 0.5 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.88 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.88 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (43)
Nearest Tclin Targets
Pathways (9)
Reactome (4)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (6)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 1 | 1 | 1 | 68.8 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 1 | 68.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | claudin 8 [Source:HGNC Symbol;Acc:HGNC:2050] | |||||||
Mouse | MGI:1859286 | 54420 | ||||||
Rat | RGD:1308575 | 304124 | ||||||
Dog | claudin 8 | VGNC:53023 | 478401 | |||||
Horse | claudin 8 | VGNC:16597 | 100053505 | |||||
Publication Statistics
PubMed Score 44.88
PubMed score by year
PubTator Score 29.49
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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