Protein Classes
Protein Summary
Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an i ...more
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IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.64 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 43.64 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | claudin 8 [Source:HGNC Symbol;Acc:HGNC:2050] | |||||||
Mouse | MGI:1859286 | 54420 | ||||||
Rat | RGD:1308575 | 304124 | ||||||
Dog | claudin 8 | VGNC:53023 | 478401 | |||||
Horse | claudin 8 | VGNC:16597 | 100053505 | |||||
Pathways (9)
Reactome (4)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell junction organization | ||||
Reactome | Cell-Cell communication | ||||
Reactome | Cell-cell junction organization | ||||
Reactome | Tight junction interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell junction organization | ||||
Cell-Cell communication | ||||
Cell-cell junction organization | ||||
Tight junction interactions | ||||
Gene Ontology Terms (9)
Functions (2)
Components (6)
Processes (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (43)
1 – 10 of 43
CLDN12
Novelty: 0.04404633
Score: 0.979
Data Source: STRINGDB
CLDN16
Novelty: 0.0092505
Score: 0.926
Data Source: STRINGDB
CLDN23
Novelty: 0.12349944
Score: 0.919
Data Source: STRINGDB
CLDN11
Novelty: 0.00275436
Score: 0.913
Data Source: STRINGDB
CLDN15
Novelty: 0.02763602
Score: 0.912
Data Source: STRINGDB
CLDN4
Novelty: 0.00227337
Score: 0.912
Data Source: STRINGDB
CLDN2
Novelty: 0.00299455
Score: 0.912
Data Source: STRINGDB
CLDN3
Novelty: 0.00286252
Score: 0.911
Data Source: STRINGDB
CLDN7
Novelty: 0.00722366
Score: 0.911
Data Source: STRINGDB
CLDN10
Novelty: 0.02175843
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score 43.64
PubMed score by year
PubTator Score 29.49
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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