Tbio CLDN6 Claudin-6

Protein Summary

Description

Plays a major role in tight junction-specific obliteration of the intercellular space. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P56747
• B3KQP9
• D3DUA5

Gene Name

• CLDN6

Ensembl ID

• ENST00000328796
• ENSP00000328674
• ENSG00000184697
• ENST00000396925
• ENSP00000380131

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.72
PubMedID	0.67
cell type or tissue	0.65
ligand (protein) perturbation	0.59
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Cell Junction Protein / Tight Junction / Claudin-6

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Claudin-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.74   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 503   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.74   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 503   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0