Protein Classes
Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
- ENST00000339464
- ENSP00000341032
- ENSG00000188064
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
transcription factor binding site profile | 0.75 | ||
transcription factor | 0.7 | ||
gene perturbation | 0.68 | ||
PubMedID | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.87 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 77 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 119.87 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 77 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 42
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
corneal topography | 1 | 1 | 1 | 96.1 | |||||
heel bone mineral density | 2 | 3 | 4 | 94.3 | |||||
hematocrit | 3 | 4 | 4 | 92.2 | |||||
hemoglobin measurement | 3 | 3 | 3 | 89.5 | |||||
central corneal thickness | 3 | 2 | 0 | 3.9 | 84.3 | ||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
corneal topography | 1 | 96.1 | |||||
heel bone mineral density | 4 | 94.3 | |||||
hematocrit | 4 | 92.2 | |||||
hemoglobin measurement | 3 | 89.5 | |||||
central corneal thickness | 0 | 3.9 | 84.3 | ||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | Wnt family member 7B | 713864 | ||||||
Mouse | MGI:98962 | 22422 | ||||||
Rat | RGD:1311441 | 315196 | ||||||
Horse | Wnt family member 7B | VGNC:25049 | 100053027 | |||||
Opossum | Wnt family member 7B | 100014091 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | Wnt family member 7B | |||||
Mouse | ||||||
Rat | ||||||
Horse | Wnt family member 7B | |||||
Opossum | Wnt family member 7B | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (60)
Reactome (6)
KEGG (13)
PathwayCommons (31)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Gene Ontology Terms (49)
Functions (2)
Components (7)
Processes (40)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (117)
1 – 10 of 117
WNT7A
Novelty: 0.00421662
p_int: 0.99999993
p_ni: 7e-9
p_wrong: 6.2e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT4
Novelty: 0.00276803
p_int: 0.999971405
p_ni: 1.2e-8
p_wrong: 0.000028583
Score: 0.932
Data Source: BioPlex,STRINGDB
FZD4
Family: GPCR
Novelty: 0.00577957
Score: 0.978
Data Source: STRINGDB
LRP5
Novelty: 0.00089807
Score: 0.976
Data Source: STRINGDB
FZD1
Family: GPCR
Novelty: 0.01097201
Score: 0.975
Data Source: STRINGDB
FZD9
Family: GPCR
Novelty: 0.01414546
Score: 0.971
Data Source: STRINGDB
PORCN
Family: Enzyme
Novelty: 0.00834643
Score: 0.971
Data Source: STRINGDB
FZD3
Family: GPCR
Novelty: 0.00964507
Score: 0.969
Data Source: STRINGDB
FZD10
Family: GPCR
Novelty: 0.02786933
Score: 0.969
Data Source: STRINGDB
FZD2
Family: GPCR
Novelty: 0.00774893
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score 119.87
PubMed score by year
PubTator Score 34.22
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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GWAS Trait