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Tbio
WNT7B
Protein Wnt-7b

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314). This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339464
  • ENSP00000341032
  • ENSG00000188064
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor binding site profile
0.75
transcription factor
0.7
gene perturbation
0.68
PubMedID
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.87   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.87   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
1
1
96.1
heel bone mineral density
2
3
4
94.3
hematocrit
3
4
4
92.2
hemoglobin measurement
3
3
3
89.5
central corneal thickness
3
2
0
3.9
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
1
96.1
heel bone mineral density
4
94.3
hematocrit
4
92.2
hemoglobin measurement
3
89.5
central corneal thickness
0
3.9
84.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Wnt family member 7B
713864
Mouse
MGI:98962
22422
Rat
RGD:1311441
315196
Horse
Wnt family member 7B
VGNC:25049
100053027
Opossum
Wnt family member 7B
100014091
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Wnt family member 7B
Mouse
Rat
Horse
Wnt family member 7B
Opossum
Wnt family member 7B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56706-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (60)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Gene Ontology Terms (49)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (117)
1 – 10 of 117
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.99999993
p_ni: 7e-9
p_wrong: 6.2e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
WNT4
Tbio
Novelty: 0.00276803
p_int: 0.999971405
p_ni: 1.2e-8
p_wrong: 0.000028583
Score: 0.932
Data Source: BioPlex,STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
Score: 0.978
Data Source: STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.976
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.975
Data Source: STRINGDB
FZD9
Tbio
Family: GPCR
Novelty: 0.01414546
Score: 0.971
Data Source: STRINGDB
PORCN
Tchem
Family: Enzyme
Novelty: 0.00834643
Score: 0.971
Data Source: STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
Score: 0.969
Data Source: STRINGDB
FZD10
Tbio
Family: GPCR
Novelty: 0.02786933
Score: 0.969
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  119.87

PubMed score by year
PubTator Score  34.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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