Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncog ...more
- ENST00000290167
- ENSP00000290167
- ENSG00000162552
- WNT-4
- SERKAL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
PubMedID | 0.87 | ||
gene perturbation | 0.76 | ||
cellular component | 0.7 | ||
pathway | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 364.04 (req: < 5)
Gene RIFs: 62 (req: <= 3)
Antibodies: 408 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 364.04 (req: >= 5)
Gene RIFs: 62 (req: > 3)
Antibodies: 408 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 58
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (199)
WNT7B
Novelty: 0.00684526
p_int: 0.999971405
p_ni: 1.2e-8
p_wrong: 0.000028583
Score: 0.932
Data Source: BioPlex,STRINGDB
CBWD3
Novelty: 0.03639787
p_int: 0.999872852
p_ni: 0.000127147
p_wrong: 1e-9
Data Source: BioPlex
WNT5A
Novelty: 0.00125563
p_int: 0.989300332
p_ni: 0.010599654
p_wrong: 0.000100014
Score: 0.959
Data Source: BioPlex,STRINGDB
WLS
Novelty: 0.01459149
p_int: 0.983537431
p_ni: 0.016462569
Score: 0.987
Data Source: BioPlex,STRINGDB
N4BP2L2
Novelty: 0.24527466
p_int: 0.976870109
p_ni: 0.023129862
p_wrong: 2.9e-8
Data Source: BioPlex
PASK
Family: Kinase
Novelty: 0.14004084
p_int: 0.969582742
p_ni: 0.030417258
Score: 0.223
Data Source: BioPlex,STRINGDB
ITPA
Family: Enzyme
Novelty: 0.00235169
p_int: 0.952572789
p_ni: 0.00096972
p_wrong: 0.046457491
Score: 0.177
Data Source: BioPlex,STRINGDB
MTCH2
Novelty: 0.01794294
p_int: 0.909942394
p_ni: 0.09005756
p_wrong: 4.6e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
TOMM40
Novelty: 0.0041507
p_int: 0.909849471
p_ni: 0.090150529
Score: 0.189
Data Source: BioPlex,STRINGDB
FSTL1
Novelty: 0.00557848
p_int: 0.901120898
p_ni: 0.075721384
p_wrong: 0.023157719
Score: 0.514
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
Pathways (68)
Reactome (10)
KEGG (15)
PathwayCommons (29)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Negative regulation of TCF-dependent signaling by WNT ligand antagonists | ||||
Reactome | PCP/CE pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Negative regulation of TCF-dependent signaling by WNT ligand antagonists | ||||
PCP/CE pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (68)
Functions (3)
Components (10)
Processes (55)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 9 | 13 | 98.8 | |||||
bone density | 8 | 7 | 11 | 93.5 | |||||
4 | 3 | 0 | 1.1 | 88.8 | |||||
BMI-adjusted hip circumference | 3 | 11 | 11 | 82.6 | |||||
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 80.6 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 13 | 98.8 | |||||
bone density | 11 | 93.5 | |||||
0 | 1.1 | 88.8 | |||||
BMI-adjusted hip circumference | 11 | 82.6 | |||||
BMI-adjusted waist-hip ratio | 2 | 80.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:98957 | 22417 | ||||||
Rat | RGD:621348 | 84426 | ||||||
Dog | Wnt family member 4 | VGNC:48424 | 612367 | |||||
Horse | Wnt family member 4 | VGNC:25046 | 100071678 | |||||
Cow | Wnt family member 4 | VGNC:36959 | 789600 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 4 | |||||
Horse | Wnt family member 4 | |||||
Cow | Wnt family member 4 | |||||
Publication Statistics
PubMed Score 364.04
PubMed score by year
PubTator Score 137.67
PubTator score by year
Related Publications
Text Mined References (93)
GeneRif Annotations (62)
Items per page:
0 of 0
PMID | Year | Title |
---|