Tbio WNT4 Protein Wnt-4

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P56705
• B4DJF9
• Q5TZQ0
• Q96T81
• Q9BXF5
• Q9H1J8
• Q9UJM2

Gene Name

• WNT4

Ensembl ID

• ENST00000290167
• ENSP00000290167
• ENSG00000162552

Symbol

• WNT-4
• SERKAL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
PubMedID	0.87
gene perturbation	0.76
cellular component	0.7
pathway	0.69

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-4

DTO Classes

Protein / Signaling / Protein Wnt-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.04   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 408   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.04   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (199)

Explore Interacting Targets

1 – 10 of 199

• See Interactions on String-DB

WNT7B

Tbio

Novelty:  0.00684526

p_int:  0.999971405

p_ni:  1.2e-8

p_wrong:  0.000028583

Score:  0.932

Data Source:  BioPlex,STRINGDB

CBWD3

Tdark

Novelty:  0.03639787

p_int:  0.999872852

p_ni:  0.000127147

p_wrong:  1e-9

Data Source:  BioPlex

WNT5A

Tbio

Novelty:  0.00125563

p_int:  0.989300332

p_ni:  0.010599654

p_wrong:  0.000100014

Score:  0.959

Data Source:  BioPlex,STRINGDB

WLS

Tbio

Novelty:  0.01459149

p_int:  0.983537431

p_ni:  0.016462569

Score:  0.987

Data Source:  BioPlex,STRINGDB

N4BP2L2

Tbio

Novelty:  0.24527466

p_int:  0.976870109

p_ni:  0.023129862

p_wrong:  2.9e-8

Data Source:  BioPlex

PASK

Tchem

Family:  Kinase

Novelty:  0.14004084

p_int:  0.969582742

p_ni:  0.030417258

Score:  0.223

Data Source:  BioPlex,STRINGDB

ITPA

Tbio

Family:  Enzyme

Novelty:  0.00235169

p_int:  0.952572789

p_ni:  0.00096972

p_wrong:  0.046457491

Score:  0.177

Data Source:  BioPlex,STRINGDB

MTCH2

Tbio

Novelty:  0.01794294

p_int:  0.909942394

p_ni:  0.09005756

p_wrong:  4.6e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

TOMM40

Tbio

Novelty:  0.0041507

p_int:  0.909849471

p_ni:  0.090150529

Score:  0.189

Data Source:  BioPlex,STRINGDB

FSTL1

Tbio

Novelty:  0.00557848

p_int:  0.901120898

p_ni:  0.075721384

p_wrong:  0.023157719

Score:  0.514

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (4)

Explore Nearest Tclin Targets

Upstream (2)

Downstream (2)

1 – 2 of 2

THRB

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  1

1: Thyroid hormone signaling pathway

THRA

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  1

1: Thyroid hormone signaling pathway

Pathways (68)

Reactome (10)

KEGG (15)

PathwayCommons (29)

WikiPathways (14)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15 targets	R-HSA-3772470
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15 targets	R-HSA-3772470
PCP/CE pathway	93 targets	R-HSA-4086400

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (68)

Functions (3)

Components (10)

Processes (55)

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1 – 3 of 3

GO Term	Evidence	Assigned by
receptor ligand activity	Inferred from Direct Assay (IDA)	BHF-UCL
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription corepressor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (19)

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5

1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	9	13		98.8
bone density	EFO_0003923	8	7	11		93.5
uterine fibroid	EFO_0000731	4	3	0	1.1	88.8
BMI-adjusted hip circumference	EFO_0008039	3	11	11		82.6
BMI-adjusted waist-hip ratio	EFO_0007788	2	2	2		80.6

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5

1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	13		98.8
bone density	EFO_0003923	11		93.5
uterine fibroid	EFO_0000731	0	1.1	88.8
BMI-adjusted hip circumference	EFO_0008039	11		82.6
BMI-adjusted waist-hip ratio	EFO_0007788	2		80.6

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UniProt Keyword Find Similar Targets

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Alternative splicing
Complete proteome
Developmental protein
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
alkaline phosphatase measurement
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
bone density
cognitive function measurement
endometriosis
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
limbs/digits/tail phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	wingless-type MMTV integration site family, member 4	MGI:98957	22417
Rat	Wnt family member 4	RGD:621348	84426
Dog	Wnt family member 4	VGNC:48424	612367
Horse	Wnt family member 4	VGNC:25046	100071678
Cow	Wnt family member 4	VGNC:36959	789600

Species	Name	OMA	EggNOG	Inparanoid
Mouse	wingless-type MMTV integration site family, member 4
Rat	Wnt family member 4
Dog	Wnt family member 4
Horse	Wnt family member 4
Cow	Wnt family member 4

Publication Statistics

PubMed Score 364.04

PubMed score by year

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PubTator Score 137.67

PubTator score by year

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Related Publications

Text Mined References (93)

GeneRif Annotations (62)

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PMID	Year	Title