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Tbio
WNT4
Protein Wnt-4

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncog ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290167
  • ENSP00000290167
  • ENSG00000162552

Symbol
  • WNT-4
  • SERKAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.87
gene perturbation
0.76
cellular component
0.7
pathway
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.5   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.5   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
6
4
7
97.9
BMI-adjusted waist-hip ratio
1
1
1
90.9
2
2
0
1.2
89.6
pelvic organ prolapse
1
1
0
1.2
83.3
heel bone mineral density
1
1
1
46.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
7
97.9
BMI-adjusted waist-hip ratio
1
90.9
0
1.2
89.6
pelvic organ prolapse
0
1.2
83.3
heel bone mineral density
1
46.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:98957
22417
Rat
RGD:621348
84426
Dog
Wnt family member 4
VGNC:48424
612367
Horse
Wnt family member 4
VGNC:25046
100071678
Cow
Wnt family member 4
VGNC:36959
789600
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
Wnt family member 4
Horse
Wnt family member 4
Cow
Wnt family member 4
Pathways (68)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
PCP/CE pathway
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Class B/2 (Secretin family receptors)
GPCR ligand binding
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
PCP/CE pathway
Gene Ontology Terms (68)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (199)
1 – 10 of 199
WNT7B
Tbio
Novelty: 0.00684526
p_int: 0.999971405
p_ni: 1.2e-8
p_wrong: 0.000028583
Score: 0.932
Data Source: BioPlex,STRINGDB
CBWD3
Tdark
Novelty: 0.03639787
p_int: 0.999872852
p_ni: 0.000127147
p_wrong: 1e-9
Data Source: BioPlex
WNT5A
Tbio
Novelty: 0.00125563
p_int: 0.989300332
p_ni: 0.010599654
p_wrong: 0.000100014
Score: 0.959
Data Source: BioPlex,STRINGDB
WLS
Tbio
Novelty: 0.01459149
p_int: 0.983537431
p_ni: 0.016462569
Score: 0.987
Data Source: BioPlex,STRINGDB
N4BP2L2
Tbio
Novelty: 0.24527466
p_int: 0.976870109
p_ni: 0.023129862
p_wrong: 2.9e-8
Data Source: BioPlex
PASK
Tbio
Family: Kinase
Novelty: 0.14004084
p_int: 0.969582742
p_ni: 0.030417258
Score: 0.223
Data Source: BioPlex,STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
p_int: 0.952572789
p_ni: 0.00096972
p_wrong: 0.046457491
Score: 0.177
Data Source: BioPlex,STRINGDB
MTCH2
Tbio
Novelty: 0.01794294
p_int: 0.909942394
p_ni: 0.09005756
p_wrong: 4.6e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
TOMM40
Tbio
Novelty: 0.0041507
p_int: 0.909849471
p_ni: 0.090150529
Score: 0.189
Data Source: BioPlex,STRINGDB
FSTL1
Tbio
Novelty: 0.00557848
p_int: 0.901120898
p_ni: 0.075721384
p_wrong: 0.023157719
Score: 0.514
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  350.50

PubMed score by year
PubTator Score  137.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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