Tchem WNT3A Protein Wnt-3a

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P56704
• Q3SY79
• Q3SY80
• Q969P2

Gene Name

• WNT3A

Ensembl ID

• ENST00000284523
• ENSP00000284523
• ENSG00000154342

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.86
pathway	0.7
PubMedID	0.68
cellular component	0.66

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Protein Wnt-3a

DTO Classes

Protein / Signaling / Protein Wnt-3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.64   (req: < 5)

Gene RIFs: 142   (req: <= 3)

Antibodies: 567   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.64   (req: >= 5)

Gene RIFs: 142   (req: > 3)

Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (16)

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1 – 10 of 16

CHEMBL1086580

WNT3ATchem

pKd : 7

CHEMBL2419698

WNT3ATchem

pIC50 : 8.44

CCT251545

WNT3ATchem

pKd : 8.42

CHEMBL2419706

WNT3ATchem

pIC50 : 8.46

CHEMBL2419705

WNT3ATchem

pIC50 : 7.97

CHEMBL2419701

WNT3ATchem

pIC50 : 7.77

CHEMBL2419702

WNT3ATchem

pIC50 : 7.96

CHEMBL2419697

WNT3ATchem

pIC50 : 7.64

CHEMBL2419700

WNT3ATchem

pIC50 : 7.51

CHEMBL2419699

WNT3ATchem

pIC50 : 7.8

Protein-Protein Interactions (328)

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• See Interactions on String-DB

WNT3

Tchem

Novelty:  0.00498299

p_int:  1

Score:  0.951

Data Source:  BioPlex,STRINGDB

PPP2R5A

Tchem

Family:  Enzyme

Novelty:  0.03073487

p_int:  0.999999987

p_ni:  1.1e-8

p_wrong:  2e-9

Score:  0.923

Data Source:  BioPlex,STRINGDB

PPP2R5B

Tbio

Family:  Enzyme

Novelty:  0.08980945

p_int:  0.999998331

p_ni:  5.2e-8

p_wrong:  0.000001617

Score:  0.928

Data Source:  BioPlex,STRINGDB

PPP2R5E

Tbio

Family:  Enzyme

Novelty:  0.05974697

p_int:  0.999997337

p_ni:  0.000002663

Score:  0.913

Data Source:  BioPlex,STRINGDB

PPP2R5D

Tbio

Family:  Enzyme

Novelty:  0.03990599

p_int:  0.9990866

p_ni:  0.0009134

Score:  0.912

Data Source:  BioPlex,STRINGDB

PPP2R1B

Tbio

Family:  Enzyme

Novelty:  0.03936638

p_int:  0.95936684

p_ni:  0.040633152

p_wrong:  8e-9

Score:  0.919

Data Source:  BioPlex,STRINGDB

PPP2R2D

Tbio

Family:  Enzyme

Novelty:  0.0658328

p_int:  0.879673013

p_ni:  0.120326987

Score:  0.156

Data Source:  BioPlex,STRINGDB

CANX

Tbio

Novelty:  0.00087002

p_int:  0.875298024

p_ni:  0.124701976

Score:  0.171

Data Source:  BioPlex,STRINGDB

SDF2L1

Tbio

Novelty:  0.12184663

p_int:  0.851809787

p_ni:  0.148190213

Data Source:  BioPlex

FEM1B

Tbio

Novelty:  0.06746412

p_int:  0.795382409

p_ni:  0.204617567

p_wrong:  2.3e-8

Data Source:  BioPlex

Nearest Tclin Targets (3)

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Upstream (1)

Downstream (2)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  12

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  8 more common pathways

Pathways (78)

Reactome (14)

KEGG (14)

PathwayCommons (33)

WikiPathways (17)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	GPCR ligand binding	460 targets	R-HSA-500792

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Disassembly of the destruction complex and recruitment of AXIN to the membrane	31 targets	R-HSA-4641262
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
GPCR ligand binding	460 targets	R-HSA-500792

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (89)

Functions (6)

Components (12)

Processes (71)

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1 – 6 of 6

GO Term	Evidence	Assigned by
receptor ligand activity	Inferred from Direct Assay (IDA)	BHF-UCL
co-receptor binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
signaling receptor binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
frizzled binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl
transcription coactivator activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (6)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	2	1	0	1.2	46.1
birth weight	EFO_0004344	1	1	1		33.1
Moyamoya disease	Orphanet_2573	1	1	0	1.6	30.2
diastolic blood pressure	EFO_0006336	1	1	1		21.5
body height	EFO_0004339	1	1	1		21.1

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1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	0	1.2	46.1
birth weight	EFO_0004344	1		33.1
Moyamoya disease	Orphanet_2573	0	1.6	30.2
diastolic blood pressure	EFO_0006336	1		21.5
body height	EFO_0004339	1		21.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis
Agents acting on the renin-angiotensin system use measurement
birth weight
body height
diastolic blood pressure
Moyamoya disease

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
growth/size/body region phenotype
limbs/digits/tail phenotype
mortality/aging
nervous system phenotype
renal/urinary system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 3A	VGNC:10887	100615247
Mouse	wingless-type MMTV integration site family, member 3A	MGI:98956	22416
Dog	Wnt family member 3A	VGNC:54800	482208
Pig	Wnt family member 3A		100514950
Opossum	Wnt family member 3A [Source:HGNC Symbol;Acc:HGNC:15983]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	Wnt family member 3A
Mouse	wingless-type MMTV integration site family, member 3A
Dog	Wnt family member 3A
Pig	Wnt family member 3A
Opossum	Wnt family member 3A [Source:HGNC Symbol;Acc:HGNC:15983]

Publication Statistics

PubMed Score 812.64

PubMed score by year

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PubTator Score 411.37

PubTator score by year

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Related Publications

Text Mined References (184)

GeneRif Annotations (142)

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PMID	Year	Title