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Tchem
WNT3A
Protein Wnt-3a

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20093360, PubMed:21244856, PubMed:24841207, PubMed:26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed:26902720). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284523
  • ENSP00000284523
  • ENSG00000154342
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.86
pathway
0.7
PubMedID
0.68
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.64   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.64   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 77
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (328)
WNT3
Tchem
Novelty:  0.00498299
p_int:  1
Score:  0.951
Data Source:  BioPlex,STRINGDB
PPP2R5A
Tchem
Family:  Enzyme
Novelty:  0.03073487
p_int:  0.999999987
p_ni:  1.1e-8
p_wrong:  2e-9
Score:  0.923
Data Source:  BioPlex,STRINGDB
PPP2R5B
Tbio
Family:  Enzyme
Novelty:  0.08980945
p_int:  0.999998331
p_ni:  5.2e-8
p_wrong:  0.000001617
Score:  0.928
Data Source:  BioPlex,STRINGDB
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.999997337
p_ni:  0.000002663
Score:  0.913
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.9990866
p_ni:  0.0009134
Score:  0.912
Data Source:  BioPlex,STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.95936684
p_ni:  0.040633152
p_wrong:  8e-9
Score:  0.919
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.879673013
p_ni:  0.120326987
Score:  0.156
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.875298024
p_ni:  0.124701976
Score:  0.171
Data Source:  BioPlex,STRINGDB
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.851809787
p_ni:  0.148190213
Data Source:  BioPlex
FEM1B
Tbio
Novelty:  0.06746412
p_int:  0.795382409
p_ni:  0.204617567
p_wrong:  2.3e-8
Data Source:  BioPlex
Pathways (78)
Class B/2 (Secretin family receptors) (R-HSA-373080)

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Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disease
Diseases of signal transduction
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (89)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
2
1
0
1.2
46.1
birth weight
1
1
1
33.1
1
1
0
1.6
30.2
diastolic blood pressure
1
1
1
21.5
body height
1
1
1
21.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.2
46.1
birth weight
1
33.1
0
1.6
30.2
diastolic blood pressure
1
21.5
body height
1
21.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 3A
VGNC:10887
100615247
Mouse
MGI:98956
22416
Dog
Wnt family member 3A
VGNC:54800
482208
Pig
Wnt family member 3A
100514950
Opossum
Wnt family member 3A [Source:HGNC Symbol;Acc:HGNC:15983]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 3A
Mouse
Dog
Wnt family member 3A
Pig
Wnt family member 3A
Opossum
Wnt family member 3A [Source:HGNC Symbol;Acc:HGNC:15983]
Publication Statistics
PubMed Score 812.64
PubMed score by year
PubTator Score 411.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title