Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse stu ...more
- ENST00000225512
- ENSP00000225512
- ENSG00000108379
- ENST00000611547
- ENSP00000478327
- ENSG00000277626
- ENST00000616347
- ENSP00000480990
- ENSG00000277641
- INT4
- INT4
- TETAMS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.92 | ||
trait | 0.86 | ||
gene perturbation | 0.82 | ||
PubMedID | 0.77 | ||
transcription factor | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.9 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 365 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.9 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 365 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 37
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (37)
Protein-Protein Interactions (151)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (63)
Reactome (7)
KEGG (14)
PathwayCommons (30)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (3)
Components (9)
Processes (27)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (100)
Items per page:
1 – 5 of 100
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
balding measurement | 1 | 2 | 2 | 95.7 | ||||||
balding measurement | 1 | 2 | 2 | 95.7 | ||||||
neuroticism measurement | 4 | 9 | 5 | 6.9 | 94.9 | |||||
neuroticism measurement | 4 | 9 | 5 | 6.9 | 94.9 | |||||
serum urea measurement | 1 | 3 | 3 | 93.2 | ||||||
Items per page:
1 – 5 of 100
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
balding measurement | 2 | 95.7 | |||||
balding measurement | 2 | 95.7 | |||||
neuroticism measurement | 5 | 6.9 | 94.9 | ||||
neuroticism measurement | 5 | 6.9 | 94.9 | ||||
serum urea measurement | 3 | 93.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 3 | VGNC:51747 | 107966366 | |||||
Macaque | Wnt family member 3 | 716909 | ||||||
Mouse | MGI:98955 | 22415 | ||||||
Rat | RGD:3972 | 24882 | ||||||
Horse | Wnt family member 3 | VGNC:49293 | 100049880 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Wnt family member 3 | |||||
Macaque | Wnt family member 3 | |||||
Mouse | ||||||
Rat | ||||||
Horse | Wnt family member 3 | |||||
Publication Statistics
PubMed Score 178.90
PubMed score by year
PubTator Score 117.82
PubTator score by year
Related Publications
Text Mined References (63)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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