You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
WNT3
Proto-oncogene Wnt-3

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse stu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225512
  • ENSP00000225512
  • ENSG00000108379
  • ENST00000611547
  • ENSP00000478327
  • ENSG00000277626
  • ENST00000616347
  • ENSP00000480990
  • ENSG00000277641

Symbol
  • INT4
  • INT4
  • TETAMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
trait
0.86
gene perturbation
0.82
PubMedID
0.77
transcription factor
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.9   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.9   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (151)
WNT3A
Tchem
Novelty:  0.00119275
p_int:  1
Score:  0.951
Data Source:  BioPlex,STRINGDB
FZD1
Tchem
Family:  GPCR
Novelty:  0.01097201
Score:  0.985
Data Source:  STRINGDB
FZD7
Tchem
Family:  GPCR
Novelty:  0.00916448
Score:  0.983
Data Source:  STRINGDB
RYK
Tbio
Family:  Kinase
Novelty:  0.00910227
Score:  0.979
Data Source:  Reactome,STRINGDB
FZD4
Tchem
Family:  GPCR
Novelty:  0.00577957
Score:  0.974
Data Source:  STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.974
Data Source:  STRINGDB
WLS
Tbio
Novelty:  0.01459149
Score:  0.973
Data Source:  STRINGDB
FZD9
Tbio
Family:  GPCR
Novelty:  0.01414546
Score:  0.973
Data Source:  STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
Score:  0.973
Data Source:  STRINGDB
FZD5
Tbio
Family:  GPCR
Novelty:  0.01673829
Score:  0.971
Data Source:  STRINGDB
Pathways (63)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (100)
Items per page:
1 – 5 of 100
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
2
2
95.7
balding measurement
1
2
2
95.7
neuroticism measurement
4
9
5
6.9
94.9
neuroticism measurement
4
9
5
6.9
94.9
serum urea measurement
1
3
3
93.2
Items per page:
1 – 5 of 100
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
95.7
balding measurement
2
95.7
neuroticism measurement
5
6.9
94.9
neuroticism measurement
5
6.9
94.9
serum urea measurement
3
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 3
VGNC:51747
107966366
Macaque
Wnt family member 3
716909
Mouse
MGI:98955
22415
Rat
RGD:3972
24882
Horse
Wnt family member 3
VGNC:49293
100049880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 3
Macaque
Wnt family member 3
Mouse
Rat
Horse
Wnt family member 3
Publication Statistics
PubMed Score 178.90
PubMed score by year
PubTator Score 117.82
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title