Tchem WNT3 Proto-oncogene Wnt-3

Protein Summary

Description

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P56703
• Q2M237
• Q9H1J9

Gene Name

• WNT3

Ensembl ID

• ENST00000225512
• ENSP00000225512
• ENSG00000108379
• ENST00000611547
• ENSP00000478327
• ENSG00000277626
• ENST00000616347
• ENSP00000480990
• ENSG00000277641

Symbol

• INT4
• INT4
• TETAMS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
trait	0.86
gene perturbation	0.82
PubMedID	0.77
transcription factor	0.7

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Proto-oncogene Wnt-3

DTO Classes

Protein / Signaling / Proto-oncogene Wnt-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.87   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 365   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.87   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0