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Tclin
KCNQ4
Potassium voltage-gated channel subfamily KQT member 4

Protein Summary
Description
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineura ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347132
  • ENSP00000262916
  • ENSG00000117013
  • ENST00000509682
  • ENSP00000423756
  • ENST00000642618
  • ENSP00000494128

Symbol
  • DFNA2
  • KV7.4
  • DFNA2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
molecular function
0.79
microRNA
0.69
transcription factor
0.65
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.01   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.01   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
72
62.2
QT interval
1
1
1
53.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
72
62.2
QT interval
1
53.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily Q member 4
VGNC:8060
456800
Mouse
MGI:1926803
60613
Dog
potassium voltage-gated channel subfamily Q member 4
VGNC:42290
482451
Cow
potassium voltage-gated channel subfamily Q member 4
VGNC:30489
528741
Pig
potassium voltage-gated channel subfamily Q member 4
100526228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily Q member 4
Mouse
Dog
potassium voltage-gated channel subfamily Q member 4
Cow
potassium voltage-gated channel subfamily Q member 4
Pig
potassium voltage-gated channel subfamily Q member 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56696-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (157)
1 – 10 of 157
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.947
Data Source: STRINGDB
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.944
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.924
Data Source: STRINGDB
KCNQ3
Tclin
Family: IC
Novelty: 0.00547886
Score: 0.882
Data Source: STRINGDB
KCNJ4
Tchem
Family: IC
Novelty: 0.0093539
Score: 0.868
Data Source: STRINGDB
KCNJ12
Tchem
Family: IC
Novelty: 0.00885141
Score: 0.855
Data Source: STRINGDB
KCNJ2
Tchem
Family: IC
Novelty: 0.00290395
Score: 0.853
Data Source: STRINGDB
KCNQ1
Tclin
Family: IC
Novelty: 0.0008956
Score: 0.826
Data Source: STRINGDB
KCNQ2
Tclin
Family: IC
Novelty: 0.00209684
Score: 0.816
Data Source: STRINGDB
KCNQ5
Tclin
Family: IC
Novelty: 0.01271842
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  168.01

PubMed score by year
PubTator Score  103.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer