Tbio NME5 Nucleoside diphosphate kinase homolog 5

Protein Summary

Description

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

Uniprot Accession IDs

• P56597
• B2R5G7
• NDK-H 5

Gene Name

• NME5

Ensembl ID

• ENST00000265191
• ENSP00000265191
• ENSG00000112981

Symbol

• NM23H5
• RSPH23
• NM23-H5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
molecular function	0.91
PubMedID	0.61
histone modification site profile	0.59
small molecule perturbation	0.55

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Nucleoside Diphosphate Kinase Homolog 5

DTO Classes

Protein / Kinase / Unclassified Protein / Nucleoside Diphosphate Kinase Homolog 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.3   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.3   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0