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Tbio
ARL4C
ADP-ribosylation factor-like protein 4C

Protein Summary
Description
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in the GDP-bound form. Regulates the microtubule-dependent intracellular vesicular transport from early endosome to recycling endosome process. ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339728
  • ENSP00000339754
  • ENSG00000188042
  • ENST00000390645
  • ENSP00000375057

Symbol
  • ARL7
  • LAK
  • ARL7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
transcription factor perturbation
0.99
molecular function
0.95
small molecule perturbation
0.85
kinase perturbation
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.36   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.999999058
p_ni:  7.86e-7
p_wrong:  1.56e-7
Score:  0.697
Data Source:  BioPlex,STRINGDB
DCUN1D4
Tchem
Novelty:  1.30623399
p_int:  0.999995737
p_ni:  0.000004156
p_wrong:  1.07e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
RGS12
Tbio
Novelty:  0.02857864
p_int:  0.999987339
p_ni:  0.000010426
p_wrong:  0.000002234
Score:  0.298
Data Source:  BioPlex,STRINGDB
FBXO33
Tdark
Novelty:  0.23409767
p_int:  0.999891828
p_ni:  1.48e-7
p_wrong:  0.000108024
Score:  0.248
Data Source:  BioPlex,STRINGDB
DIRAS1
Tbio
Family:  Enzyme
Novelty:  0.13332903
p_int:  0.999601756
p_ni:  0.000398238
p_wrong:  6e-9
Score:  0.673
Data Source:  BioPlex,STRINGDB
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.998156822
p_ni:  0.001842978
p_wrong:  2.01e-7
Data Source:  BioPlex
RAD51B
Tbio
Novelty:  0.00302521
p_int:  0.994077031
p_ni:  0.005909009
p_wrong:  0.000013961
Score:  0.554
Data Source:  BioPlex,STRINGDB
NKIRAS1
Tbio
Family:  Enzyme
Novelty:  0.11289799
p_int:  0.993028519
p_ni:  0.006413745
p_wrong:  0.000557736
Score:  0.248
Data Source:  BioPlex,STRINGDB
DNAJC12
Tbio
Novelty:  0.05214775
p_int:  0.988934752
p_ni:  0.011065247
p_wrong:  1e-9
Data Source:  BioPlex
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.986989971
p_ni:  0.013008803
p_wrong:  0.000001227
Score:  0.192
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
1
1
1
11.7
central corneal thickness
1
1
0
2.3
1.3
blood pressure
1
1
0
3.3
0.8
response to dietary potassium supplementation
1
1
0
3.3
0.8
response to high sodium diet
1
1
0
3.3
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
1
11.7
central corneal thickness
0
2.3
1.3
blood pressure
0
3.3
0.8
response to dietary potassium supplementation
0
3.3
0.8
response to high sodium diet
0
3.3
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 4C
VGNC:10575
740726
Macaque
ADP ribosylation factor like GTPase 4C
715121
Mouse
MGI:2445172
320982
Dog
ADP ribosylation factor like GTPase 4C
VGNC:38113
100685179
Horse
ADP ribosylation factor like GTPase 4C
VGNC:15517
100057460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 4C
Macaque
ADP ribosylation factor like GTPase 4C
Mouse
Dog
ADP ribosylation factor like GTPase 4C
Horse
ADP ribosylation factor like GTPase 4C
Publication Statistics
PubMed Score 28.36
PubMed score by year
PubTator Score 35.96
PubTator score by year
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Related Publications
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PMID
Year
Title