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Tdark
TMEM50B
Transmembrane protein 50B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420455
  • ENSP00000397773
  • ENSG00000142188
  • ENST00000542230
  • ENSP00000439768
  • ENST00000571778
  • ENSP00000458900
  • ENSG00000263160
  • ENST00000573374
  • ENSP00000460121

Symbol
  • C21orf4
  • C21orf4
  • HCVP7TP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.99
histone modification site profile
0.89
disease perturbation
0.83
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
67.8
2
1
0
1.1
67.8
1
2
0
1.1
39.4
1
2
0
1.1
39.4
1
1
0
1.1
33.1
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.8
0
1.1
67.8
0
1.1
39.4
0
1.1
39.4
0
1.1
33.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 50B
VGNC:14683
746665
Macaque
transmembrane protein 50B
699352
Mouse
MGI:1925225
77975
Rat
RGD:1307561
360698
Dog
transmembrane protein 50B
478405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 50B
Macaque
transmembrane protein 50B
Mouse
Rat
Dog
transmembrane protein 50B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56557-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (41)
1 – 10 of 41
DONSON
Tbio
Novelty:  0.05354868
Score:  0.751
Data Source:  STRINGDB
LEPROTL1
Tdark
Novelty:  0.01484804
Score:  0.71
Data Source:  STRINGDB
MRPS6
Tbio
Novelty:  0.15569626
Score:  0.705
Data Source:  STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
Score:  0.697
Data Source:  STRINGDB
LEPROT
Tbio
Novelty:  0.06240483
Score:  0.667
Data Source:  STRINGDB
DOP1B
Tbio
Novelty:  0.14441699
Score:  0.604
Data Source:  STRINGDB
PAXBP1
Tbio
Novelty:  0.13631396
Score:  0.579
Data Source:  STRINGDB
DSCR3
Tbio
Novelty:  0.05414856
Score:  0.563
Data Source:  STRINGDB
DDI2
Tbio
Novelty:  0.09288646
Score:  0.545
Data Source:  STRINGDB
GART
Tclin
Novelty:  0.00524985
Score:  0.545
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.93

PubMed score by year
PubTator Score  0.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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