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Tclin
NDUFA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000498737
  • ENSP00000418842
  • ENSG00000184983
  • ENST00000605916
  • ENSP00000475402
  • ENSG00000272765
  • ENST00000628740
  • ENSP00000486781
  • ENSG00000277365
  • ENST00000630201
  • ENSP00000487431
  • ENSG00000281013
  • ENST00000630971
  • ENSP00000487462
  • ENSG00000273397

Symbol
  • LYRM6
  • NADHB14
  • B14
  • LYRM6
  • CI-B14
  • MC1DN33
  • NADHB14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
virus perturbation
0.92
histone modification site profile
0.91
transcription factor binding site profile
0.82


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A6
VGNC:53403
458981
Mouse
MGI:1914380
67130
Rat
RGD:1309818
315167
Dog
NADH:ubiquinone oxidoreductase subunit A6
VGNC:43689
474483
Horse
NADH:ubiquinone oxidoreductase subunit A6
VGNC:20626
100070817
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A6
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit A6
Horse
NADH:ubiquinone oxidoreductase subunit A6
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56556-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (226)
1 – 10 of 226
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999532976
p_ni: 0.000467024
Score: 0.999
Data Source: BioPlex,STRINGDB
TOM1L2
Tdark
Novelty: 0.1647296
p_int: 0.99686957
p_ni: 0.00313043
Score: 0.622
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.949518109
p_ni: 0.050481891
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.943681246
p_ni: 0.056318754
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.87117963
p_ni: 0.128820369
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
Score: 0.999
Data Source: STRINGDB
NDUFB2
Tclin
Family: Enzyme
Novelty: 0.05735054
Score: 0.999
Data Source: STRINGDB
NDUFAB1
Tclin
Novelty: 0.00190242
Score: 0.999
Data Source: STRINGDB
NDUFS1
Tclin
Family: Enzyme
Novelty: 0.0215624
Score: 0.999
Data Source: STRINGDB
NDUFA4
Tclin
Family: Enzyme
Novelty: 0.03103013
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  86.49

PubMed score by year
PubTator Score  141.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer