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Tclin
NDUFA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000498737
  • ENSP00000418842
  • ENSG00000184983
  • ENST00000605916
  • ENSP00000475402
  • ENSG00000272765
  • ENST00000628740
  • ENSP00000486781
  • ENSG00000277365
  • ENST00000630201
  • ENSP00000487431
  • ENSG00000281013
  • ENST00000630971
  • ENSP00000487462
  • ENSG00000273397

Symbol
  • LYRM6
  • NADHB14
  • B14
  • LYRM6
  • CI-B14
  • MC1DN33
  • NADHB14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
virus perturbation
0.92
histone modification site profile
0.91
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 957   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 957   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1