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Tchem
CTBP2
C-terminal-binding protein 2

Protein Summary
Description
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309035
  • ENSP00000311825
  • ENSG00000175029
  • ENST00000334808
  • ENSP00000357816
  • ENST00000337195
  • ENSP00000338615
  • ENST00000411419
  • ENSP00000410474
  • ENST00000494626
  • ENSP00000436285
  • ENST00000531469
  • ENSP00000434630
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.97
disease perturbation
0.96
molecular function
0.88
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.3   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.3   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
95
age-related hearing impairment
1
1
0
8.3
91.5
chronotype measurement
1
1
1
60.3
refractive error measurement
1
1
1
58.1
lifestyle measurement
1
1
1
56.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
95
age-related hearing impairment
0
8.3
91.5
chronotype measurement
1
60.3
refractive error measurement
1
58.1
lifestyle measurement
1
56.1
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-terminal binding protein 2
695124
Mouse
MGI:1201686
13017
Rat
RGD:68372
81717
Dog
C-terminal binding protein 2
VGNC:39687
100684514
Horse
C-terminal binding protein 2
VGNC:16925
100056830
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-terminal binding protein 2
Mouse
Rat
Dog
C-terminal binding protein 2
Horse
C-terminal binding protein 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56545-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Degradation of beta-catenin by the destruction complex (R-HSA-195253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Repression of WNT target genes
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Degradation of beta-catenin by the destruction complex
Disease
Diseases of signal transduction
Repression of WNT target genes
Signal Transduction
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (139)
1 – 10 of 139
CTBP1
Tbio
Novelty: 0.00243818
p_int: 0.999808555
p_ni: 0.000191445
Score: 0.959
Data Source: BioPlex,STRINGDB
SNTG1
Tbio
Novelty: 0.05608114
p_int: 0.989436258
p_ni: 0.010563742
Data Source: BioPlex
LCOR
Tbio
Family: TF
Novelty: 0.01638762
p_int: 0.964949596
p_ni: 0.035050404
Score: 0.34
Data Source: BioPlex,STRINGDB
ZBTB42
Tbio
Family: TF
Novelty: 0.54038505
p_int: 0.948344385
p_ni: 0.05165557
p_wrong: 4.5e-8
Score: 0.221
Data Source: BioPlex,STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.0016117
p_int: 0.900862941
p_ni: 0.099137059
Score: 0.768
Data Source: BioPlex,STRINGDB
IGFBP1
Tchem
Novelty: 0.0006975
p_int: 0.785928364
p_ni: 0.214071636
Score: 0.638
Data Source: BioPlex,STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.772293941
p_ni: 0.227706056
p_wrong: 3e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.955
Data Source: STRINGDB
TLE4
Tbio
Novelty: 0.02094922
Score: 0.948
Data Source: STRINGDB
TLE1
Tbio
Novelty: 0.00594261
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  207.30

PubMed score by year
PubTator Score  80.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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