Protein Summary
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564). This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alt ...more
- ENST00000343849
- ENSP00000341940
- ENSG00000182533
- ENST00000397368
- ENSP00000380525
- LQT9
- MPDT
- RMD2
- VIP21
- LGMD1C
- VIP-21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
cell type or tissue | 0.84 | ||
molecular function | 0.79 | ||
cellular component | 0.75 | ||
biological term | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 512.51 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 264 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 512.51 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 264 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 72
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (243)
ANKRD13C
Novelty: 1.5309683
p_int: 0.999999058
p_ni: 9.42e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
ENDOD1
Family: Enzyme
Novelty: 0.26430864
p_int: 0.999998886
p_ni: 0.000001114
Data Source: BioPlex
CEP95
Novelty: 1.18897795
p_int: 0.99999226
p_ni: 0.000007615
p_wrong: 1.25e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
CENPT
Novelty: 0.03878936
p_int: 0.999984769
p_ni: 0.000015161
p_wrong: 7e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
MIS18BP1
Novelty: 0.05688807
p_int: 0.999983346
p_ni: 0.000016645
p_wrong: 1e-8
Score: 0.663
Data Source: BioPlex,STRINGDB
CAV1
Novelty: 0.00035244
p_int: 0.999885841
p_ni: 0.000113977
p_wrong: 1.83e-7
Score: 0.825
Data Source: BioPlex,STRINGDB
GTSE1
Family: Enzyme
Novelty: 0.0460569
p_int: 0.999832601
p_ni: 0.000167399
Score: 0.185
Data Source: BioPlex,STRINGDB
REEP1
Novelty: 0.02280713
p_int: 0.999792003
p_ni: 0.000066016
p_wrong: 0.000141981
Score: 0.527
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (7)
Upstream (5)
Downstream (2)
1 – 5 of 5
Pathways (24)
Reactome (2)
KEGG (5)
PathwayCommons (1)
WikiPathways (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Muscle contraction | ||||
Reactome | Smooth Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Muscle contraction | ||||
Smooth Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (87)
Functions (11)
Components (15)
Processes (61)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 1 | 0 | 1.1 | 63.1 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
chronotype measurement | 0 | 1.1 | 63.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | caveolin 3 | VGNC:1753 | 738786 | |||||
Macaque | caveolin 3 | 702163 | ||||||
Mouse | MGI:107570 | 12391 | ||||||
Rat | RGD:2281 | 29161 | ||||||
Dog | caveolin 3 | VGNC:38753 | 484671 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | caveolin 3 | |||||
Macaque | caveolin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | caveolin 3 | |||||
Publication Statistics
PubMed Score 512.51
PubMed score by year
PubTator Score 311.75
PubTator score by year
Related Publications
Text Mined References (114)
GeneRif Annotations (77)
Items per page:
0 of 0
PMID | Year | Title |
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