Tbio CAV3 Caveolin-3

Protein Summary

Description

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564). This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P56539
• A8K777
• Q3T1A4

Gene Name

• CAV3

Ensembl ID

• ENST00000343849
• ENSP00000341940
• ENSG00000182533
• ENST00000397368
• ENSP00000380525

Symbol

• LQT9
• MPDT
• RMD2
• VIP21
• LGMD1C
• VIP-21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
cell type or tissue	0.84
molecular function	0.79
cellular component	0.75
biological term	0.73

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Caveolin-3

Protein / Structural Protein / Caveolin-3

Protein / Membrane Traffic Protein / Caveolin-3

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-3

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Caveolin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.92   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.92   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0