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Tbio
EIF6
Eukaryotic translation initiation factor 6

Protein Summary
Description
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374436
  • ENSP00000363559
  • ENSG00000242372
  • ENST00000374443
  • ENSP00000363566
  • ENST00000374450
  • ENSP00000363574

Symbol
  • EIF3A
  • ITGB4BP
  • CAB
  • EIF3A
  • eIF-6
  • p27BBP
  • ITGB4BP
  • b(2)gcn
  • p27(BBP)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.88
interacting protein
0.85
hub protein
0.79
tissue
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.67   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.67   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
44
reticulocyte count
1
1
1
29.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
44
reticulocyte count
1
29.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 6
VGNC:6100
458200
Macaque
eukaryotic translation initiation factor 6
709602
Mouse
MGI:1196288
16418
Rat
RGD:1305373
305506
Dog
eukaryotic translation initiation factor 6
VGNC:54648
477210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 6
Macaque
eukaryotic translation initiation factor 6
Mouse
Rat
Dog
eukaryotic translation initiation factor 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56537-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ribosome biogenesis in eukaryotes
Name
Explore in Pharos
Explore in Source
Ribosome biogenesis in eukaryotes
Protein-Protein Interactions (312)
1 – 10 of 312
BCCIP
Tbio
Novelty: 0.02710491
p_int: 0.999334713
p_ni: 0.000665287
Score: 0.816
Data Source: BioPlex,STRINGDB
RPL4
Tbio
Novelty: 0.00475169
Score: 0.988
Data Source: STRINGDB
NMD3
Tbio
Novelty: 0.03505289
Score: 0.986
Data Source: STRINGDB
NIP7
Tbio
Novelty: 0.05885055
Score: 0.985
Data Source: STRINGDB
EBNA1BP2
Tbio
Novelty: 0.02083466
Score: 0.983
Data Source: STRINGDB
RPL5
Tbio
Novelty: 0.00663792
Score: 0.983
Data Source: STRINGDB
GTPBP4
Tbio
Novelty: 0.00062563
Score: 0.98
Data Source: STRINGDB
RPL9
Tbio
Novelty: 0.00845583
Score: 0.978
Data Source: STRINGDB
RPL31
Tbio
Novelty: 0.03427872
Score: 0.978
Data Source: STRINGDB
MRTO4
Tbio
Novelty: 0.06676322
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.67

PubMed score by year
PubTator Score  63.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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