Tchem LGALS4 Galectin-4

Protein Summary

Description

Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P56470
• Gal-4

Gene Name

• LGALS4

Ensembl ID

• ENST00000307751
• ENSP00000302100
• ENSG00000171747
• ENST00000634573
• ENSP00000489411
• ENSG00000282992

Symbol

• GAL4
• L36LBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
gene perturbation	0.82
interacting protein	0.74
small molecule perturbation	0.67
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Galectin-4

Protein / Cell Adhesion Molecule / Galectin-4

DTO Classes

Protein / Signaling / Galectin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6526.01   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 333   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6526.01   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0