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Tchem
LGALS4
Galectin-4

Protein Summary
Description
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307751
  • ENSP00000302100
  • ENSG00000171747
  • ENST00000634573
  • ENSP00000489411
  • ENSG00000282992

Symbol
  • GAL4
  • L36LBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
gene perturbation
0.82
interacting protein
0.74
small molecule perturbation
0.67
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5345.92   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5345.92   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (183)
1 – 10 of 183
ELAVL4
Tbio
Novelty: 0.00260383
Score: 0.923
Data Source: STRINGDB
ELAVL3
Tbio
Novelty: 0.00143503
Score: 0.923
Data Source: STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
Score: 0.923
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00110045
Score: 0.875
Data Source: STRINGDB
CHD7
Tbio
Family: Epigenetic
Novelty: 0.00065444
Score: 0.794
Data Source: STRINGDB
PAICS
Tbio
Novelty: 0.00215277
Score: 0.768
Data Source: STRINGDB
NOTUM
Tchem
Family: Enzyme
Novelty: 0.02044587
Score: 0.746
Data Source: STRINGDB
PHGDH
Tbio
Family: Enzyme
Novelty: 0.00047542
Score: 0.735
Data Source: STRINGDB
SHKBP1
Tbio
Novelty: 0.00235279
Score: 0.725
Data Source: STRINGDB
SPANXA1
Tbio
Novelty: 0.04707594
Score: 0.71
Data Source: STRINGDB
Publication Statistics
PubMed Score  5345.92

PubMed score by year
PubTator Score  622.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer