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Tbio
ATP5ME
ATP synthase subunit e, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304312
  • ENSP00000306003
  • ENSG00000169020

Symbol
  • ATP5I
  • ATP5K
  • ATP5I
  • ATP5K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase membrane subunit e
VGNC:49035
461042
Mouse
MGI:106636
11958
Rat
RGD:621377
140608
Dog
ATP synthase membrane subunit e
100684805
Horse
ATP synthase membrane subunit e
VGNC:51142
100629290
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase membrane subunit e
Mouse
Rat
Dog
ATP synthase membrane subunit e
Horse
ATP synthase membrane subunit e
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56385-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Protein-Protein Interactions (180)
1 – 10 of 180
ATP5PF
Tbio
Family: Enzyme
Novelty: 0.00585408
p_int: 0.99971306
p_ni: 0.00028694
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP5F1D
Tbio
Family: Enzyme
Novelty: 0.07296539
p_int: 0.787700268
p_ni: 0.212299722
p_wrong: 1.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
ATP5MG
Tbio
Family: Enzyme
Novelty: 0.16555751
Score: 0.999
Data Source: STRINGDB
ATP5PD
Tbio
Family: Enzyme
Novelty: 0.0730514
Score: 0.999
Data Source: STRINGDB
ATP5PB
Tbio
Family: Enzyme
Novelty: 0.07345384
Score: 0.999
Data Source: STRINGDB
ATP5PO
Tbio
Family: Enzyme
Novelty: 0.01038964
Score: 0.999
Data Source: STRINGDB
ATP5F1E
Tbio
Family: Enzyme
Novelty: 0.01870657
Score: 0.999
Data Source: STRINGDB
ATP5F1B
Tbio
Family: Enzyme
Novelty: 0.01053177
Score: 0.998
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.998
Data Source: STRINGDB
ATP5MF
Tbio
Family: Enzyme
Novelty: 0.00707678
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.00

PubMed score by year
PubTator Score  2.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer