You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
P2RX3
P2X purinoceptor 3

Protein Summary
Description
Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity). This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263314
  • ENSP00000263314
  • ENSG00000109991

Symbol
  • P2X3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.79
cell type or tissue
0.76
cellular component
0.6
gene perturbation
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.77   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.77   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1308
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
0
1.8
49.6
triglyceride measurement
1
1
1
20.3
eosinophil percentage of leukocytes
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
0
1.8
49.6
triglyceride measurement
1
20.3
eosinophil percentage of leukocytes
1
11.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 3
742961
Macaque
purinergic receptor P2X 3
706503
Mouse
MGI:1097160
228139
Rat
RGD:620253
81739
Dog
purinergic receptor P2X 3
VGNC:44209
448782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
purinergic receptor P2X 3
Macaque
purinergic receptor P2X 3
Mouse
Rat
Dog
purinergic receptor P2X 3
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56373-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Elevation of cytosolic Ca2+ levels (R-HSA-139853)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Reactome
Platelet calcium homeostasis
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Elevation of cytosolic Ca2+ levels
Hemostasis
Platelet calcium homeostasis
Platelet homeostasis
Protein-Protein Interactions (66)
1 – 10 of 66
P2RX2
Tchem
Family: IC
Novelty: 0.00241146
Score: 0.94
Data Source: STRINGDB
P2RX6
Tchem
Family: IC
Novelty: 0.02091945
Score: 0.911
Data Source: STRINGDB
P2RX7
Tchem
Family: IC
Novelty: 0.00090502
Score: 0.91
Data Source: STRINGDB
P2RX1
Tchem
Family: IC
Novelty: 0.00286826
Score: 0.908
Data Source: STRINGDB
P2RX5
Tchem
Family: IC
Novelty: 0.01591178
Score: 0.908
Data Source: STRINGDB
P2RX4
Tchem
Family: IC
Novelty: 0.00242958
Score: 0.907
Data Source: STRINGDB
TRPV1
Tclin
Family: IC
Novelty: 0.00039493
Score: 0.857
Data Source: STRINGDB
P2RY1
Tchem
Family: GPCR
Novelty: 0.00203299
Score: 0.809
Data Source: STRINGDB
ZNF77
Tbio
Family: TF
Novelty: 0.00135172
Score: 0.806
Data Source: STRINGDB
P2RY4
Tchem
Family: GPCR
Novelty: 0.00903213
Score: 0.771
Data Source: STRINGDB
Publication Statistics
PubMed Score  506.77

PubMed score by year
PubTator Score  183.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: