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Tbio
POLE2
DNA polymerase epsilon subunit 2

Protein Summary
Description
Participates in DNA repair and in chromosomal DNA replication. DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216367
  • ENSP00000216367
  • ENSG00000100479
  • ENST00000539565
  • ENSP00000446313
  • ENST00000554396
  • ENSP00000451621

Symbol
  • DPE2
  • DPE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.84
gene perturbation
0.83
pathway
0.68
small molecule perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.93   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.93   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (324)
POLE
Tclin
Family:  Enzyme
Novelty:  0.00371129
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.999899453
p_ni:  0.000096883
p_wrong:  0.000003664
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
p_int:  0.993770641
p_ni:  0.006229359
p_wrong:  1e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
p_int:  0.988908717
p_ni:  0.006857916
p_wrong:  0.004233367
Data Source:  BioPlex
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.986989971
p_ni:  0.013008803
p_wrong:  0.000001227
Score:  0.192
Data Source:  BioPlex,STRINGDB
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.98029972
p_ni:  0.019700268
p_wrong:  1.2e-8
Score:  0.54
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.977020035
p_ni:  0.022979938
p_wrong:  2.8e-8
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.972140037
p_ni:  0.027859959
p_wrong:  4e-9
Data Source:  BioPlex
C16orf45
Tbio
Novelty:  0.00913059
p_int:  0.964905987
p_ni:  0.035094008
p_wrong:  5e-9
Score:  0.223
Data Source:  BioPlex,STRINGDB
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
p_int:  0.95738081
p_ni:  0.009318427
p_wrong:  0.033300763
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
POLE
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  3
POLA1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  1
Pathways (42)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Base Excision Repair
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Base Excision Repair
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.8
14.2
age at onset
1
1
0
3.8
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.8
14.2
age at onset
0
3.8
14.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase epsilon 2, accessory subunit
VGNC:8291
452888
Macaque
DNA polymerase epsilon 2, accessory subunit
707526
Mouse
MGI:1197514
18974
Rat
RGD:1311962
299112
Horse
DNA polymerase epsilon 2, accessory subunit
VGNC:21657
100065785
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase epsilon 2, accessory subunit
Macaque
DNA polymerase epsilon 2, accessory subunit
Mouse
Rat
Horse
DNA polymerase epsilon 2, accessory subunit
Publication Statistics
PubMed Score 32.93
PubMed score by year
PubTator Score 14.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title