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Tbio
ITGA1
Integrin alpha-1

Protein Summary
Description
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282588
  • ENSP00000282588
  • ENSG00000213949

Symbol
  • VLA1
  • CD49a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.86
protein domain
0.85
PubMedID
0.79
disease
0.78
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.96   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.96   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
3
11
83.7
heel bone mineral density
2
1
2
83.1
reticulocyte measurement
3
5
10
78.7
low density lipoprotein cholesterol measurement
3
2
3
77.5
C-reactive protein measurement
1
1
1
73.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
11
83.7
heel bone mineral density
2
83.1
reticulocyte measurement
10
78.7
low density lipoprotein cholesterol measurement
3
77.5
C-reactive protein measurement
1
73.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 1
VGNC:4053
461880
Mouse
MGI:96599
109700
Rat
RGD:2923
25118
Dog
integrin subunit alpha 1
VGNC:42120
489210
Horse
integrin subunit alpha 1
VGNC:19160
100063434
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 1
Mouse
Rat
Dog
integrin subunit alpha 1
Horse
integrin subunit alpha 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56199-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (132)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
Developmental Biology
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Axon guidance
CHL1 interactions
Developmental Biology
Extracellular matrix organization
Hemostasis
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (228)
1 – 10 of 228
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999999656
p_ni: 8.4e-8
p_wrong: 2.6e-7
Score: 0.333
Data Source: BioPlex,STRINGDB
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999998433
p_ni: 0.00000155
p_wrong: 1.7e-8
Score: 0.351
Data Source: BioPlex,STRINGDB
LMAN2L
Tbio
Novelty: 0.04364985
p_int: 0.999528202
p_ni: 0.000075677
p_wrong: 0.000396122
Score: 0.189
Data Source: BioPlex,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.986
Data Source: Reactome,STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.969
Data Source: STRINGDB
ITGB5
Tbio
Novelty: 0.01455909
Score: 0.968
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.96
Data Source: STRINGDB
ITGB7
Tclin
Novelty: 0.01290005
Score: 0.959
Data Source: STRINGDB
LAMA1
Tbio
Novelty: 0.00852401
Score: 0.958
Data Source: STRINGDB
ITGB8
Tbio
Novelty: 0.01564348
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  170.96

PubMed score by year
PubTator Score  122.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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