Tchem MARS Methionine--tRNA ligase, cytoplasmic

Protein Summary

Description

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P56192
• B3KVK7
• Q14895
• Q53H14
• Q96A15
• Q96BZ0
• Q9NSE0

Gene Name

• MARS

Ensembl ID

• ENST00000262027
• ENSP00000262027
• ENSG00000166986
• ENST00000537638
• ENSP00000446168

Symbol

• MRS
• ILLD
• CMT2U
• ILFS2
• METRS
• MTRNS
• SPG70

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.95
disease perturbation	0.93
molecular function	0.93
transcription factor binding site profile	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.63   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.63   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (28)

Explore Active Ligands

1 – 10 of 28

CHEMBL304237

MARSTchem Enzyme

pIC50 : 9

CHEMBL1163059

MARSTchem Enzyme

pIC50 : 8.15

CHEMBL58615

MARSTchem Enzyme

pIC50 : 7.92

CHEMBL55652

MARSTchem Enzyme

pIC50 : 7.75

CHEMBL56582

MARSTchem Enzyme

pIC50 : 7.4

CHEMBL57382

MARSTchem Enzyme

pIC50 : 7.16

CHEMBL59204

MARSTchem Enzyme

pIC50 : 7.06

CHEMBL72005

MARSTchem Enzyme

pIC50 : 6.89

CHEMBL307342

MARSTchem Enzyme

pIC50 : 6.89

CHEMBL308349

MARSTchem Enzyme

pIC50 : 6.82

Protein-Protein Interactions (317)

Explore Interacting Targets

1 – 10 of 317

• See Interactions on String-DB

KARS

Tchem

Family:  Enzyme

Novelty:  0.00386511

p_int:  0.997545984

p_ni:  0.002454016

Score:  0.998

Data Source:  BioPlex,STRINGDB

RARS

Tchem

Family:  Enzyme

Novelty:  0.00099479

p_int:  0.990818864

p_ni:  0.009181136

Score:  0.999

Data Source:  BioPlex,STRINGDB

SDCBP

Tbio

Novelty:  0.00242211

p_int:  0.966404844

p_ni:  0.033595156

Score:  0.808

Data Source:  BioPlex,STRINGDB

LARS

Tchem

Family:  Enzyme

Novelty:  0.00361711

p_int:  0.963443269

p_ni:  0.036556731

Score:  0.999

Data Source:  BioPlex,STRINGDB

AIMP1

Tbio

Family:  Enzyme

Novelty:  0.00743447

p_int:  0.947072728

p_ni:  0.052927272

Score:  0.999

Data Source:  BioPlex,STRINGDB

QARS

Tchem

Family:  Enzyme

Novelty:  0.01684657

p_int:  0.933796971

p_ni:  0.066203029

Score:  0.999

Data Source:  BioPlex,STRINGDB

EPRS

Tchem

Family:  Enzyme

Novelty:  0.00084896

Score:  0.999

Data Source:  STRINGDB

EEF1E1

Tbio

Novelty:  0.06216577

Score:  0.999

Data Source:  STRINGDB

IARS

Tchem

Family:  Enzyme

Novelty:  0.00539046

Score:  0.999

Data Source:  STRINGDB

AIMP2

Tchem

Family:  Enzyme

Novelty:  0.03283387

Score:  0.998

Data Source:  STRINGDB

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Downstream (1)

1 – 1 of 1

TXNRD1

Tclin

Family:  Enzyme

KEGG Distance:  2

Common Pathways:  1

1: Selenocompound metabolism

Pathways (13)

Reactome (7)

KEGG (3)

PathwayCommons (2)

WikiPathways (1)

Cytosolic tRNA aminoacylation (R-HSA-379716)

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5

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Selenoamino acid metabolism	119 targets	R-HSA-2408522

Name	Explore in Pharos	Explore in Source
Cytosolic tRNA aminoacylation	24 targets	R-HSA-379716
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Metabolism of proteins	2050 targets	R-HSA-392499
Selenoamino acid metabolism	119 targets	R-HSA-2408522

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (3)

Components (6)

Processes (8)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
methionine-tRNA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
tRNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (27)

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5

1 – 5 of 27

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	6	5	7	5.2	98.6
high density lipoprotein cholesterol measurement	EFO_0004612	8	7	17		97.3
triglyceride measurement	EFO_0004530	7	6	13	2.7	89.8
glomerular filtration rate	EFO_0005208	3	2	3		89
apolipoprotein A 1 measurement	EFO_0004614	2	2	2		84.9

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	7	5.2	98.6
high density lipoprotein cholesterol measurement	EFO_0004612	17		97.3
triglyceride measurement	EFO_0004530	13	2.7	89.8
glomerular filtration rate	EFO_0005208	3		89
apolipoprotein A 1 measurement	EFO_0004614	2		84.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Aminoacyl-tRNA synthetase
ATP-binding
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Disease mutation
Ligase
Neurodegeneration

GWAS Trait Find Similar Targets

No Header	No Header
amyotrophic lateral sclerosis
apolipoprotein A 1 measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
blood urea nitrogen measurement
coronary artery disease
creatinine measurement
follistatin measurement
glomerular filtration rate
glucose measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	methionyl-tRNA synthetase	VGNC:13216	452016
Macaque	methionyl-tRNA synthetase		714744
Mouse	methionine-tRNA synthetase	MGI:1345633	216443
Rat	methionyl-tRNA synthetase	RGD:1305321	299851
Dog	methionyl-tRNA synthetase	VGNC:43027	474414

Species	Name	OMA	EggNOG	Inparanoid
Chimp	methionyl-tRNA synthetase
Macaque	methionyl-tRNA synthetase
Mouse	methionine-tRNA synthetase
Rat	methionyl-tRNA synthetase
Dog	methionyl-tRNA synthetase

Publication Statistics

PubMed Score 66.63

PubMed score by year

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PubTator Score 132.49

PubTator score by year

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Related Publications

Text Mined References (45)

GeneRif Annotations (14)

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10

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PMID	Year	Title