Tchem MARS Methionine--tRNA ligase, cytoplasmic

Protein Summary

Description

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• P56192
• B3KVK7
• Q14895
• Q53H14
• Q96A15
• Q96BZ0
• Q9NSE0

Gene Name

• MARS

Ensembl ID

• ENST00000262027
• ENSP00000262027
• ENSG00000166986
• ENST00000537638
• ENSP00000446168

Symbol

• MRS
• ILLD
• CMT2U
• ILFS2
• METRS
• MTRNS
• SPG70

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	0.95
disease perturbation	0.93
molecular function	0.93
transcription factor binding site profile	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.89   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.89   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0