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Tchem
MARS
Methionine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262027
  • ENSP00000262027
  • ENSG00000166986
  • ENST00000537638
  • ENSP00000446168

Symbol
  • MRS
  • ILLD
  • CMT2U
  • ILFS2
  • METRS
  • MTRNS
  • SPG70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.95
disease perturbation
0.93
molecular function
0.93
transcription factor binding site profile
0.89


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.03   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.03   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionyl-tRNA synthetase
VGNC:13216
452016
Macaque
methionyl-tRNA synthetase
714744
Mouse
MGI:1345633
216443
Rat
RGD:1305321
299851
Dog
methionyl-tRNA synthetase
VGNC:43027
474414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionyl-tRNA synthetase
Macaque
methionyl-tRNA synthetase
Mouse
Rat
Dog
methionyl-tRNA synthetase
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56192-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (317)
1 – 10 of 317
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
p_int: 0.997545984
p_ni: 0.002454016
Score: 0.998
Data Source: BioPlex,STRINGDB
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.990818864
p_ni: 0.009181136
Score: 0.999
Data Source: BioPlex,STRINGDB
SDCBP
Tbio
Novelty: 0.00242211
p_int: 0.966404844
p_ni: 0.033595156
Score: 0.808
Data Source: BioPlex,STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
p_int: 0.963443269
p_ni: 0.036556731
Score: 0.999
Data Source: BioPlex,STRINGDB
AIMP1
Tbio
Family: Enzyme
Novelty: 0.00743447
p_int: 0.947072728
p_ni: 0.052927272
Score: 0.999
Data Source: BioPlex,STRINGDB
QARS
Tchem
Family: Enzyme
Novelty: 0.01684657
p_int: 0.933796971
p_ni: 0.066203029
Score: 0.999
Data Source: BioPlex,STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.999
Data Source: STRINGDB
EEF1E1
Tbio
Novelty: 0.06216577
Score: 0.999
Data Source: STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.999
Data Source: STRINGDB
AIMP2
Tbio
Family: Enzyme
Novelty: 0.03283387
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  65.03

PubMed score by year
PubTator Score  132.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer