You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I. The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340344
  • ENSP00000342895
  • ENSG00000160194
  • ENST00000354250
  • ENSP00000346196

Symbol
  • CI-10k
  • CI-9KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.94
histone modification site profile
0.9
gene perturbation
0.85
disease perturbation
0.83
cellular component
0.74


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
Rendered image for metformin
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NADH:ubiquinone oxidoreductase subunit V3
722400
Mouse
MGI:1890894
78330
Rat
RGD:621020
64539
Dog
NADH:ubiquinone oxidoreductase subunit V3
VGNC:43712
478421
Horse
NADH:ubiquinone oxidoreductase subunit V3
100057691
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NADH:ubiquinone oxidoreductase subunit V3
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit V3
Horse
NADH:ubiquinone oxidoreductase subunit V3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P56181-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (126)
1 – 10 of 126
FAM185A
Tdark
Novelty:  2.58347979
p_int:  0.99999999
p_ni:  9e-9
Data Source:  BioPlex
NDUFB7
Tclin
Family:  Enzyme
Novelty:  0.14580093
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
NDUFB6
Tclin
Family:  Enzyme
Novelty:  0.075245
p_int:  0.999999979
p_ni:  1.6e-8
p_wrong:  5e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
NDUFB9
Tclin
Family:  Enzyme
Novelty:  0.00715628
p_int:  0.999999601
p_ni:  3.14e-7
p_wrong:  8.5e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.999999246
p_ni:  7.35e-7
p_wrong:  1.9e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
MT-ND1
Tclin
Family:  Enzyme
Novelty:  0.00090183
p_int:  0.999999047
p_ni:  9.53e-7
Score:  0.986
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.99999829
p_ni:  0.00000171
Score:  0.994
Data Source:  BioPlex,STRINGDB
NDUFS4
Tclin
Family:  Enzyme
Novelty:  0.00787292
p_int:  0.99999818
p_ni:  0.000001815
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MT-ND5
Tclin
Family:  Enzyme
Novelty:  0.00223164
p_int:  0.999995391
p_ni:  0.000004522
p_wrong:  8.6e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
NDUFV2
Tclin
Family:  Enzyme
Novelty:  0.02240263
p_int:  0.99999412
p_ni:  0.00000588
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.06

PubMed score by year
PubTator Score  4.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer