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Tbio
DLX1
Homeobox protein DLX-1

Protein Summary
Description
Plays a role as a transcriptional activator or repressor (PubMed:14671321). Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (PubMed:14671321). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina (By similarity). Likely to play a regulatory role in the development of the ventral forebrain (By similarity). May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity). This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily memb ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341900
  • ENSP00000341786
  • ENSG00000144355
  • ENST00000361725
  • ENSP00000354478
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
transcription factor binding site profile
0.77
histone modification site profile
0.76
biological process
0.73
protein domain
0.73


Related Tools
GENEVA
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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.47   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.47   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 1
VGNC:165
459740
Mouse
MGI:94901
13390
Rat
RGD:1309593
296500
Dog
distal-less homeobox 1
VGNC:39989
607766
Horse
distal-less homeobox 1
VGNC:17220
100053103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 1
Mouse
Rat
Dog
distal-less homeobox 1
Horse
distal-less homeobox 1
Protein-Protein Interactions (110)
1 – 10 of 110
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.969
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.911
Data Source: STRINGDB
IRX1
Tbio
Family: TF
Novelty: 0.01754936
Score: 0.786
Data Source: STRINGDB
LHX6
Tbio
Family: TF
Novelty: 0.01603143
Score: 0.776
Data Source: STRINGDB
MEIS2
Tbio
Family: TF
Novelty: 0.01393828
Score: 0.759
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.744
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.701
Data Source: STRINGDB
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.7
Data Source: STRINGDB
LHX8
Tbio
Family: TF
Novelty: 0.01815234
Score: 0.698
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.696
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.47

PubMed score by year
PubTator Score  28.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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