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Tbio
GFRA1
GDNF family receptor alpha-1

Protein Summary
Description
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity). This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355422
  • ENSP00000347591
  • ENSG00000151892
  • ENST00000369234
  • ENSP00000358237
  • ENST00000369236
  • ENSP00000358239
  • ENST00000439649
  • ENSP00000393725

Symbol
  • GDNFRA
  • RETL1
  • TRNR1
  • GDNFR
  • RET1L
  • RETL1
  • TRNR1
  • GDNFRA
  • GFR-ALPHA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
gene perturbation
0.95
cell type or tissue
0.7
phenotype
0.7
transcription factor
0.68


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.33   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.33   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GDNF family receptor alpha 1
VGNC:7228
450756
Macaque
GDNF family receptor alpha 1
706353
Mouse
MGI:1100842
14585
Rat
Dog
GDNF family receptor alpha 1
VGNC:41189
609114
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GDNF family receptor alpha 1
Macaque
GDNF family receptor alpha 1
Mouse
Rat
Dog
GDNF family receptor alpha 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56159-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
Protein-Protein Interactions (100)
1 – 10 of 100
GDNF
Tbio
Novelty:  0.00036702
Score:  0.996
Data Source:  Reactome,STRINGDB
RET
Tclin
Family:  Kinase
Novelty:  0.00028324
Score:  0.987
Data Source:  Reactome,STRINGDB
NRTN
Tbio
Novelty:  0.00547984
Score:  0.986
Data Source:  Reactome,STRINGDB
PSPN
Tbio
Novelty:  0.02169895
Score:  0.975
Data Source:  Reactome,STRINGDB
ARTN
Tbio
Novelty:  0.00799442
Score:  0.972
Data Source:  Reactome,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.956
Data Source:  Reactome,STRINGDB
FRS2
Tbio
Novelty:  0.00654052
Score:  0.928
Data Source:  Reactome,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.918
Data Source:  Reactome,STRINGDB
GFRA3
Tbio
Novelty:  0.10149548
Score:  0.916
Data Source:  Reactome,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  250.33

PubMed score by year
PubTator Score  123.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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