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Tbio
BID
BH3-interacting domain death agonist

Protein Summary
Description
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317361
  • ENSP00000318822
  • ENSG00000015475
  • ENST00000342111
  • ENSP00000344594
  • ENST00000399765
  • ENSP00000382667
  • ENST00000399767
  • ENSP00000382669
  • ENST00000399774
  • ENSP00000382674
  • ENST00000551952
  • ENSP00000449236
  • ENST00000611040
  • ENSP00000483709
  • ENST00000614949
  • ENSP00000477773
  • ENST00000615414
  • ENSP00000483534
  • ENST00000622694
  • ENSP00000480414

Symbol
  • FP497
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.98
virus perturbation
0.98
transcription factor perturbation
0.97
kinase perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.92   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 1203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.92   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 1203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
92.7
leukocyte count
1
2
2
85
lymphocyte percentage of leukocytes
1
1
1
67.1
eosinophil count
2
1
2
63.4
neutrophil percentage of leukocytes
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
92.7
leukocyte count
2
85
lymphocyte percentage of leukocytes
1
67.1
eosinophil count
2
63.4
neutrophil percentage of leukocytes
1
53.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BH3 interacting domain death agonist
VGNC:5229
458635
Macaque
BH3 interacting domain death agonist
100426724
Mouse
MGI:108093
12122
Rat
RGD:620160
64625
Dog
BH3 interacting domain death agonist
VGNC:38456
100683675
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BH3 interacting domain death agonist
Macaque
BH3 interacting domain death agonist
Mouse
Rat
Dog
BH3 interacting domain death agonist
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55957-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (68)
Activation and oligomerization of BAK protein (R-HSA-111452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation and oligomerization of BAK protein
Reactome
Activation of BAD and translocation to mitochondria
Reactome
Activation of BH3-only proteins
Reactome
Activation, myristolyation of BID and translocation to mitochondria
Reactome
Activation, translocation and oligomerization of BAX
Name
Explore in Pharos
Explore in Source
Activation and oligomerization of BAK protein
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Activation, myristolyation of BID and translocation to mitochondria
Activation, translocation and oligomerization of BAX
Protein-Protein Interactions (89)
1 – 10 of 89
BCL2L2
Tchem
Novelty:  0.00430896
p_int:  0.998423938
p_ni:  0.001576056
p_wrong:  6e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
ARL6IP6
Tdark
Novelty:  0.36643453
p_int:  0.888717606
p_ni:  0.067410262
p_wrong:  0.043872133
Score:  0.206
Data Source:  BioPlex,STRINGDB
MBD5
Tbio
Family:  Epigenetic
Novelty:  0.03015349
p_int:  0.805218732
p_ni:  0.080354123
p_wrong:  0.114427145
Score:  0.193
Data Source:  BioPlex,STRINGDB
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.999
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.999
Data Source:  Reactome,STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.999
Data Source:  STRINGDB
BAK1
Tbio
Novelty:  0.00381053
Score:  0.995
Data Source:  Reactome,STRINGDB
BAX
Tchem
Novelty:  0.00150653
Score:  0.993
Data Source:  Reactome,STRINGDB
BCL2
Tclin
Novelty:  0.00608635
Score:  0.99
Data Source:  Reactome,STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.986
Data Source:  STRINGDB
Publication Statistics
PubMed Score  50.92

PubMed score by year
PubTator Score  2011.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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