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Tclin
FCGRT
IgG receptor FcRn large subunit p51

Protein Summary
Description
Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511). This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221466
  • ENSP00000221466
  • ENSG00000104870
  • ENST00000426395
  • ENSP00000410798

Symbol
  • FCRN
  • FCRN
  • alpha-chain
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.79
biological term
0.74
gene perturbation
0.71
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.94   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.94   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
belantamab mafodotin
no chemical structure image available
Protein-Protein Interactions (132)
1 – 10 of 132
B2M
Tbio
Novelty:  0.00011248
p_int:  0.999999467
p_ni:  5.33e-7
Score:  0.963
Data Source:  BioPlex,STRINGDB
THBS1
Tchem
Novelty:  0.00073905
p_int:  0.9999972
p_ni:  0.0000028
Score:  0.191
Data Source:  BioPlex,STRINGDB
DUSP9
Tbio
Family:  Enzyme
Novelty:  0.03849148
p_int:  0.99999353
p_ni:  0.000006469
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
PRTG
Tbio
Novelty:  0.05120525
p_int:  0.999960729
p_ni:  0.000039127
p_wrong:  1.45e-7
Score:  0.571
Data Source:  BioPlex,STRINGDB
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.999954286
p_ni:  0.000045713
Score:  0.301
Data Source:  BioPlex,STRINGDB
SGCE
Tbio
Novelty:  0.00449577
p_int:  0.999947105
p_ni:  0.00005285
p_wrong:  4.5e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
p_int:  0.999937085
p_ni:  0.00006291
p_wrong:  5e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
HGFAC
Tchem
Family:  Enzyme
Novelty:  0.00620243
p_int:  0.999907921
p_ni:  0.000008815
p_wrong:  0.000083264
Data Source:  BioPlex
PCDHGA11
Tdark
Novelty:  0.44130091
p_int:  0.999870457
p_ni:  0.000129541
p_wrong:  2e-9
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.999870454
p_ni:  0.000123494
p_wrong:  0.000006052
Score:  0.247
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
11
12
99.4
serum albumin measurement
4
7
9
99.2
hemoglobin measurement
4
6
6
95.6
calcium measurement
1
4
4
95.1
hematocrit
4
5
6
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
12
99.4
serum albumin measurement
9
99.2
hemoglobin measurement
6
95.6
calcium measurement
4
95.1
hematocrit
6
93.8
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc fragment of IgG receptor and transporter
VGNC:7558
456208
Macaque
Fc fragment of IgG receptor and transporter
718859
Mouse
MGI:103017
14132
Rat
RGD:61811
29558
Dog
Fc fragment of IgG receptor and transporter
VGNC:40803
476414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc fragment of IgG receptor and transporter
Macaque
Fc fragment of IgG receptor and transporter
Mouse
Rat
Dog
Fc fragment of IgG receptor and transporter
Publication Statistics
PubMed Score 1116.94
PubMed score by year
PubTator Score 1177.67
PubTator score by year