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Tbio
RAG2
V(D)J recombination-activating protein 2

Protein Summary
Description
Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps. The RAG complex also plays a role in pre-B cell allelic exclusion, a process lea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311485
  • ENSP00000308620
  • ENSG00000175097
  • ENST00000618712
  • ENSP00000478672

Symbol
  • RAG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
molecular function
0.86
phenotype
0.78
protein domain
0.73
virus perturbation
0.64


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1070.97   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1070.97   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
recombination activating 2
VGNC:1016
466490
Macaque
recombination activating 2
716837
Mouse
MGI:97849
19374
Rat
RGD:1305588
295953
Dog
recombination activating 2
VGNC:45327
483419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
recombination activating 2
Macaque
recombination activating 2
Mouse
Rat
Dog
recombination activating 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P55895-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-7 signaling
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-7 signaling
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Gene Ontology Terms (21)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (143)
1 – 10 of 143
RAG1
Tbio
Novelty: 0.00070687
Score: 0.999
Data Source: Reactome,STRINGDB
FOXO1
Tbio
Family: TF
Novelty: 0.00058938
Score: 0.937
Data Source: STRINGDB
BRWD1
Tbio
Family: Epigenetic
Novelty: 0.09247334
Score: 0.908
Data Source: STRINGDB
MT-CYB
Tbio
Novelty: 0.00012093
Score: 0.826
Data Source: STRINGDB
IL2RG
Tclin
Novelty: 0.00108272
Score: 0.792
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.789
Data Source: STRINGDB
HMGB1
Tbio
Family: TF
Novelty: 0.00043845
Score: 0.756
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.696
Data Source: STRINGDB
IL7
Tbio
Novelty: 0.00054101
Score: 0.674
Data Source: STRINGDB
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  1070.97

PubMed score by year
PubTator Score  497.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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