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Tbio
SUMO3
Small ubiquitin-related modifier 3

Protein Summary
Description
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332859
  • ENSP00000330343
  • ENSG00000184900
  • ENST00000411651
  • ENSP00000409666

Symbol
  • SMT3A
  • SMT3H1
  • SMT3A
  • Smt3B
  • SMT3H1
  • SUMO-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
co-expressed gene
0.89
transcription factor perturbation
0.88
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.61   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 462   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.61   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 462   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
31.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1336201
20610
Rat
RGD:1561022
499417
Cow
small ubiquitin-like modifier 3
617236
Anole lizard
small ubiquitin-like modifier 3
100564314
Xenopus
small ubiquitin-like modifier 3
XB-GENE-1004211
100125978
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
small ubiquitin-like modifier 3
Anole lizard
small ubiquitin-like modifier 3
Xenopus
small ubiquitin-like modifier 3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Reactome
Nucleotide Excision Repair
Name
Explore in Pharos
Explore in Source
DNA Repair
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Nucleotide Excision Repair
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (220)
1 – 10 of 220
SENP2
Tbio
Family: Enzyme
Novelty: 0.17238834
p_int: 0.999999893
p_ni: 1.06e-7
p_wrong: 1e-9
Score: 0.98
Data Source: BioPlex,Reactome,STRINGDB
SUMO2
Tbio
Novelty: 0.00366833
p_int: 0.999212138
p_ni: 0.000787862
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
p_int: 0.997333077
p_ni: 0.002666923
Data Source: BioPlex
INPPL1
Tchem
Family: Enzyme
Novelty: 0.00634126
p_int: 0.992510665
p_ni: 0.007489335
Data Source: BioPlex
UBE2I
Tbio
Novelty: 0.00267883
p_int: 0.987642702
p_ni: 0.012357297
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SAE1
Tbio
Novelty: 0.01613881
Score: 0.997
Data Source: Reactome,STRINGDB
SENP1
Tchem
Family: Enzyme
Novelty: 0.00831213
Score: 0.995
Data Source: Reactome,STRINGDB
UBA2
Tbio
Novelty: 0.01582807
Score: 0.991
Data Source: Reactome,STRINGDB
RANBP2
Tbio
Family: Enzyme
Novelty: 0.00484823
Score: 0.986
Data Source: STRINGDB
SENP5
Tbio
Family: Enzyme
Novelty: 0.0510532
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  29.61

PubMed score by year
PubTator Score  117.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer