Tdark XG Glycoprotein Xg

Protein Summary

Description

This gene encodes the XG blood group antigen, and is located at the pseudoautosomal boundary on the short (p) arm of chromosome X. The three 5' exons reside in the pseudoautosomal region and the remaining exons within the X-specific end. A truncated copy of this gene is found on the Y chromosome at the pseudoautosomal boundary. It is transcribed, but not expected to make a Y-chromosome specific gene product. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• P55808
• E9PCH1
• Q496N8
• Q496N9
• Q496P0
• Q71BZ5

Gene Name

• XG

Ensembl ID

• ENST00000381174
• ENSP00000370566
• ENSG00000124343
• ENST00000644266
• ENSP00000494087

Symbol

• PBDX
• PBDX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.98
cell type or tissue	0.8
disease	0.66
tissue sample	0.57
cell line	0.51

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.08   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.08   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (1)

Components (1)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
integral component of plasma membrane	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (29)

Explore Interacting Targets

1 – 10 of 29

• See Interactions on String-DB

CD99

Tbio

Novelty: 0.0022425

Score: 0.8

Data Source: STRINGDB

TRAPPC2B

Tdark

Novelty: 0.02535505

Score: 0.642

Data Source: STRINGDB

ASMT

Tbio

Family: Enzyme

Novelty: 0.00313422

Score: 0.623

Data Source: STRINGDB

TRAPPC2

Tbio

Novelty: 0.01745001

Score: 0.623

Data Source: STRINGDB

CRYZL1

Tbio

Family: Enzyme

Novelty: 0.03945638

Score: 0.616

Data Source: STRINGDB

CD99L2

Tbio

Novelty: 0.16202141

Score: 0.585

Data Source: STRINGDB

ARSD

Tbio

Family: Enzyme

Novelty: 0.00669026

Score: 0.55

Data Source: STRINGDB

STS

Tchem

Family: Enzyme

Novelty: 0.0020382

Score: 0.547

Data Source: STRINGDB

ARSH

Tbio

Family: Enzyme

Novelty: 0.00554685

Score: 0.547

Data Source: STRINGDB

MAOB

Tclin

Family: Enzyme

Novelty: 0.00036833

Score: 0.54

Data Source: STRINGDB

Publication Statistics

PubMed Score  56.08

PubMed score by year

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PubTator Score  39.67

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MESWWGLPCLAFLCFLMHARGQRDFDLADALDDPEPTKKPNSDIYPKPKPPYYPQPENPDSGGNIYPRPK

1-70

PRPQPQPGNSGNSGGYFNDVDRDDGRYPPRPRPRPPAGGGGGGYSSYGNSDNTHGGDHHSTYGNPEGNMV

70-140

AKIVSPIVSVVVVTLLGAAASYFKLNNRRNCFRTHEPENV

140-180

MESWWGLPCLAFLCFLMHARGQRDFDLADALDDPEPTKKPNSDIYPKPKPPYYPQPENPDSGGNIYPRPKPRPQPQPGNSGNSGGYFNDVDRDDGRYPPRPRPRPPAGGGGGGYSSYGNSDNTHGGDHHSTYGNPEGNMVAKIVSPIVSVVVVTLLGAAASYFKLNNRRNCFRTHEPENV

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Uniprot Keyword

Alternative splicing
Blood group antigen
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane