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Tbio
HNRNPH2
Heterogeneous nuclear ribonucleoprotein H2

Protein Summary
Description
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316594
  • ENSP00000361927
  • ENSG00000126945

Symbol
  • FTP3
  • HNRPH2
  • FTP3
  • MRXSB
  • NRPH2
  • HNRPH'
  • HNRPH2
  • hnRNPH'
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
0.98
hub protein
0.88
drug perturbation
0.87
histone modification site profile
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein H2
VGNC:14689
465760
Macaque
heterogeneous nuclear ribonucleoprotein H2 [Source:HGNC Symbol;Acc:HGNC:5042]
Mouse
MGI:1201779
56258
Rat
RGD:1549784
308650
Dog
heterogeneous nuclear ribonucleoprotein H2
VGNC:41731
480989
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heterogeneous nuclear ribonucleoprotein H2
Macaque
heterogeneous nuclear ribonucleoprotein H2 [Source:HGNC Symbol;Acc:HGNC:5042]
Mouse
Rat
Dog
heterogeneous nuclear ribonucleoprotein H2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55795-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (245)
1 – 10 of 245
PLOD1
Tbio
Family: Enzyme
Novelty: 0.00905345
p_int: 0.99602563
p_ni: 0.00397437
Score: 0.392
Data Source: BioPlex,STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
p_int: 0.977219801
p_ni: 0.022780199
Data Source: BioPlex
ARHGEF39
Tdark
Novelty: 0.30447134
p_int: 0.865388034
p_ni: 0.134611966
Data Source: BioPlex
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.99
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.987
Data Source: STRINGDB
HNRNPA2B1
Tbio
Novelty: 0.00404935
Score: 0.987
Data Source: STRINGDB
HNRNPA3
Tbio
Novelty: 0.03214786
Score: 0.984
Data Source: STRINGDB
DDX5
Tbio
Family: Enzyme
Novelty: 0.00637984
Score: 0.98
Data Source: STRINGDB
SRSF2
Tbio
Novelty: 0.00207072
Score: 0.977
Data Source: STRINGDB
HNRNPC
Tbio
Novelty: 0.00136097
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.47

PubMed score by year
PubTator Score  41.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer