Tchem NPEPPS Puromycin-sensitive aminopeptidase

Protein Summary

Description

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P55786
• B7Z463
• Q6P145
• Q9NP16
• Q9UEM2
• PSA

Gene Name

• NPEPPS

Ensembl ID

• ENST00000322157
• ENSP00000320324
• ENSG00000141279

Symbol

• PSA
• PSA
• AAP-S
• MP100

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
disease perturbation	0.9
transcription factor perturbation	0.74
transcription factor	0.7
gene perturbation	0.69

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Puromycin-sensitive Aminopeptidase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Puromycin-sensitive Aminopeptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.67   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.67   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0