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Tchem
NPEPPS
Puromycin-sensitive aminopeptidase

Protein Summary
Description
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322157
  • ENSP00000320324
  • ENSG00000141279

Symbol
  • PSA
  • PSA
  • AAP-S
  • MP100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
disease perturbation
0.9
transcription factor perturbation
0.74
transcription factor
0.7
gene perturbation
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.23   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.23   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
ANTAQ
chemical structure image
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
94.1
testosterone measurement
1
1
1
88
low density lipoprotein cholesterol measurement
2
2
2
80.8
mean platelet volume
2
3
3
71.5
apolipoprotein B measurement
1
1
1
67.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
94.1
testosterone measurement
1
88
low density lipoprotein cholesterol measurement
2
80.8
mean platelet volume
3
71.5
apolipoprotein B measurement
1
67.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminopeptidase puromycin sensitive
VGNC:14185
749281
Macaque
aminopeptidase puromycin sensitive
693995
Mouse
MGI:1101358
19155
Rat
RGD:619962
50558
Dog
aminopeptidase puromycin sensitive
480538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminopeptidase puromycin sensitive
Macaque
aminopeptidase puromycin sensitive
Mouse
Rat
Dog
aminopeptidase puromycin sensitive
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P55786-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (81)
1 – 10 of 81
LRRC8E
Tbio
Novelty: 0.15689344
p_int: 0.950289665
p_ni: 0.049710335
Score: 0.39
Data Source: BioPlex,STRINGDB
UGT2B17
Tbio
Family: Enzyme
Novelty: 0.0088729
Score: 0.806
Data Source: STRINGDB
NBPF1
Tdark
Novelty: 0.18226903
Score: 0.803
Data Source: STRINGDB
HYDIN
Tbio
Novelty: 0.03318399
Score: 0.802
Data Source: STRINGDB
NBPF12
Tdark
Novelty: 0.01235433
Score: 0.801
Data Source: STRINGDB
GPRIN2
Tbio
Novelty: 0.07888894
Score: 0.8
Data Source: STRINGDB
SRGAP3
Tbio
Family: Enzyme
Novelty: 0.01913784
Score: 0.8
Data Source: STRINGDB
SRGAP2
Tbio
Family: Enzyme
Novelty: 0.02951755
Score: 0.763
Data Source: STRINGDB
DRD5
Tchem
Family: GPCR
Novelty: 0.00803909
Score: 0.752
Data Source: STRINGDB
GTF2I
Tbio
Family: TF
Novelty: 0.00703345
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.23

PubMed score by year
PubTator Score  1056.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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