Tbio CCL18 C-C motif chemokine 18

Protein Summary

Description

Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P55774
• B5BUM2
• Q53X71

Gene Name

• CCL18

Ensembl ID

• ENST00000614828
• ENSP00000483144
• ENSG00000278167
• ENST00000615723
• ENSP00000483347
• ENSG00000278006
• ENST00000616054
• ENSP00000479955
• ENSG00000275385

Symbol

• AMAC1
• DCCK1
• MIP4
• PARC
• SCYA18
• CKb7
• PARC
• AMAC1
• DCCK1
• MIP-4
• AMAC-1
• DC-CK1
• SCYA18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.91
biological term	0.73
cell line	0.61
cell type or tissue	0.58
microRNA	0.53

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 18

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 18

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.33   (req: < 5)

Gene RIFs: 136   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 322.33   (req: >= 5)

Gene RIFs: 136   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0