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Tbio
CCL23
C-C motif chemokine 23

Protein Summary
Description
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610342
  • ENSP00000483546
  • ENSG00000276114
  • ENST00000612516
  • ENSP00000484748
  • ENSG00000274736
  • ENST00000615050
  • ENSP00000481357
  • ENST00000632633
  • ENSP00000488270

Symbol
  • MIP3
  • MPIF1
  • SCYA23
  • CKb8
  • MIP3
  • Ckb-8
  • MIP-3
  • MPIF-1
  • SCYA23
  • Ckb-8-1
  • hmrp-2a
  • CK-BETA-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.6
tissue
0.59
tissue sample
0.57
cell line
0.52
virus perturbation
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.86   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.86   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fetal genotype effect measurement
1
2
2
95
fetal genotype effect measurement
1
2
2
95
protein measurement
1
2
2
95
protein measurement
1
2
2
95
C-C motif chemokine 3 measurement
1
1
1
88.5
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fetal genotype effect measurement
2
95
fetal genotype effect measurement
2
95
protein measurement
2
95
protein measurement
2
95
C-C motif chemokine 3 measurement
1
88.5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55773-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Formyl peptide receptors bind formyl peptides and many other ligands
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Formyl peptide receptors bind formyl peptides and many other ligands
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.758192206
p_ni:  0.241807794
Score:  0.303
Data Source:  BioPlex,STRINGDB
CCL21
Tbio
Novelty:  0.00130736
Score:  0.849
Data Source:  STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
Score:  0.759
Data Source:  STRINGDB
CCL24
Tbio
Novelty:  0.0071091
Score:  0.664
Data Source:  STRINGDB
CCL7
Tbio
Novelty:  0.00200389
Score:  0.657
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.642
Data Source:  STRINGDB
CCL16
Tbio
Novelty:  0.00489032
Score:  0.642
Data Source:  STRINGDB
TFAP4
Tbio
Family:  TF
Novelty:  0.03155887
Score:  0.641
Data Source:  STRINGDB
HBS1L
Tbio
Novelty:  0.00125579
Score:  0.641
Data Source:  STRINGDB
CCL19
Tbio
Novelty:  0.00169711
Score:  0.613
Data Source:  STRINGDB
Publication Statistics
PubMed Score  77.86

PubMed score by year
PubTator Score  43.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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