Tbio CCL23 C-C motif chemokine 23

Protein Summary

Description

Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P55773
• B7ZKQ3
• O00174
• O75950
• Q52LD4

Gene Name

• CCL23

Ensembl ID

• ENST00000610342
• ENSP00000483546
• ENSG00000276114
• ENST00000612516
• ENSP00000484748
• ENSG00000274736
• ENST00000615050
• ENSP00000481357
• ENST00000632633
• ENSP00000488270

Symbol

• MIP3
• MPIF1
• SCYA23
• CKb8
• MIP3
• Ckb-8
• MIP-3
• MPIF-1
• SCYA23
• Ckb-8-1
• hmrp-2a
• CK-BETA-8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.6
tissue	0.59
tissue sample	0.57
cell line	0.52
virus perturbation	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 23

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.89   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.89   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0