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Tbio
SNU13
NHP2-like protein 1

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:17412961). Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215956
  • ENSP00000215956
  • ENSG00000100138
  • ENST00000355257
  • ENSP00000347401
  • ENST00000401959
  • ENSP00000383949
  • ENST00000648674
  • ENSP00000497142

Symbol
  • NHP2L1
  • FA1
  • FA-1
  • NHPX
  • 15.5K
  • OTK27
  • SSFA1
  • NHP2L1
  • SPAG12
  • SNRNP15-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.56   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.56   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
1
1
47.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
1
47.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein 13
VGNC:14778
458869
Mouse
MGI:893586
20826
Dog
small nuclear ribonucleoprotein 13
474484
Horse
small nuclear ribonucleoprotein 13
VGNC:23407
100070695
Cow
small nuclear ribonucleoprotein 13
VGNC:35087
767931
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein 13
Mouse
Dog
small nuclear ribonucleoprotein 13
Horse
small nuclear ribonucleoprotein 13
Cow
small nuclear ribonucleoprotein 13
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55769-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (658)
1 – 10 of 658
PRPF4
Tchem
Novelty: 0.08229072
p_int: 0.942707892
p_ni: 0.057292108
Score: 0.999
Data Source: BioPlex,STRINGDB
LSM7
Tbio
Novelty: 0.09112723
p_int: 0.931257329
p_ni: 0.068742671
Score: 0.998
Data Source: BioPlex,STRINGDB
PRPF3
Tbio
Novelty: 0.01600014
p_int: 0.916209421
p_ni: 0.083790578
Score: 0.999
Data Source: BioPlex,STRINGDB
LSM3
Tbio
Novelty: 0.05044984
p_int: 0.849370179
p_ni: 0.150629821
Score: 0.998
Data Source: BioPlex,STRINGDB
RRP9
Tbio
Novelty: 0.07232317
p_int: 0.84855472
p_ni: 0.15144528
Score: 0.998
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.002157
p_int: 0.847865338
p_ni: 0.152134662
Score: 0.992
Data Source: BioPlex,STRINGDB
LSM5
Tbio
Novelty: 0.12669584
p_int: 0.795424034
p_ni: 0.204575966
Score: 0.999
Data Source: BioPlex,STRINGDB
PPIH
Tbio
Family: Enzyme
Novelty: 0.03225561
Score: 0.999
Data Source: STRINGDB
TXNL4A
Tbio
Novelty: 0.04677517
Score: 0.999
Data Source: STRINGDB
SART1
Tbio
Novelty: 0.00835627
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.56

PubMed score by year
PubTator Score  16.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer