Tbio SEC13 Protein SEC13 homolog

Protein Summary

Description

Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P55735
• A8MV37
• B4DXJ1
• Q5BJF0
• Q9BRM6
• Q9BUG7

Gene Name

• SEC13

Ensembl ID

• ENST00000337354
• ENSP00000336566
• ENSG00000157020
• ENST00000350697
• ENSP00000312122
• ENST00000383801
• ENSP00000373312
• ENST00000397109
• ENSP00000380298

Symbol

• D3S1231E
• SEC13A
• SEC13L1
• SEC13R
• SEC13R
• npp-20
• SEC13L1
• D3S1231E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.98
cellular component	0.82
transcription factor binding site profile	0.82
pathway	0.67

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Protein Sec13 Homolog

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Protein Sec13 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.2   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.2   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0