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Tbio
PKNOX1
Homeobox protein PKNOX1

Protein Summary
Description
Activates transcription in the presence of PBX1A and HOXA1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291547
  • ENSP00000291547
  • ENSG00000160199

Symbol
  • PREP1
  • PREP1
  • pkonx1c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
transcription factor binding site profile
0.87
disease perturbation
0.79
biological process
0.71
histone modification site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.28   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.28   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
3
4
4
92.6
viral load
1
1
1
64.9
blood metabolite measurement
1
1
1
50.6
neutrophil count
2
1
2
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
homocysteine measurement
4
92.6
viral load
1
64.9
blood metabolite measurement
1
50.6
neutrophil count
2
11.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PBX/knotted 1 homeobox 1
VGNC:14815
458587
Macaque
PBX/knotted 1 homeobox 1
714108
Mouse
MGI:1201409
18771
Rat
RGD:1305003
294322
Dog
PBX/knotted 1 homeobox 1
VGNC:44614
611059
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PBX/knotted 1 homeobox 1
Macaque
PBX/knotted 1 homeobox 1
Mouse
Rat
Dog
PBX/knotted 1 homeobox 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55347-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (111)
1 – 10 of 111
PBX4
Tbio
Family:  TF
Novelty:  0.09471693
p_int:  0.999999991
p_ni:  3e-9
p_wrong:  6e-9
Score:  0.741
Data Source:  BioPlex,STRINGDB
PBX1
Tbio
Family:  TF
Novelty:  0.00329442
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
p_int:  0.999999796
p_ni:  1.92e-7
p_wrong:  1.2e-8
Score:  0.83
Data Source:  BioPlex,STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.999897489
p_ni:  0.000099321
p_wrong:  0.00000319
Data Source:  BioPlex
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.999826113
p_ni:  0.00003277
p_wrong:  0.000141117
Score:  0.517
Data Source:  BioPlex,STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.989653914
p_ni:  0.000003612
p_wrong:  0.010342474
Score:  0.67
Data Source:  BioPlex,STRINGDB
VPS16
Tbio
Novelty:  0.03575558
p_int:  0.967333483
p_ni:  0.032666517
Score:  0.28
Data Source:  BioPlex,STRINGDB
ACOT7
Tbio
Family:  Enzyme
Novelty:  0.01093954
p_int:  0.952734607
p_ni:  0.047265393
Score:  0.239
Data Source:  BioPlex,STRINGDB
C5orf24
Tdark
Novelty:  3.95177775
p_int:  0.945604667
p_ni:  0.000015594
p_wrong:  0.054379738
Score:  0.719
Data Source:  BioPlex,STRINGDB
HOXB1
Tbio
Family:  TF
Novelty:  0.00731831
Score:  0.967
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  109.28

PubMed score by year
PubTator Score  30.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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