Tbio PKNOX1 Homeobox protein PKNOX1

Protein Summary

Description

Activates transcription in the presence of PBX1A and HOXA1.

Uniprot Accession IDs

• P55347
• O00528
• Q8IWT7

Gene Name

• PKNOX1

Ensembl ID

• ENST00000291547
• ENSP00000291547
• ENSG00000160199

Symbol

• PREP1
• PREP1
• pkonx1c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
transcription factor binding site profile	0.87
disease perturbation	0.79
biological process	0.71
histone modification site profile	0.69

Protein Classes

PANTHER Classes

Protein / ... / Homeodomain Transcription Factor / Homeobox Protein Pknox1

Protein / ... / Rna Binding Protein / Dna-directed Rna Polymerase / Homeobox Protein Pknox1

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Homeobox Protein Pknox1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.43   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.43   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0