You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FOXA3
Hepatocyte nuclear factor 3-gamma

Protein Summary
Description
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302177
  • ENSP00000304004
  • ENSG00000170608

Symbol
  • HNF3G
  • TCF3G
  • FKHH3
  • HNF3G
  • TCF3G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.75
protein domain
0.73
transcription factor binding site profile
0.68
histone modification site profile
0.67
molecular function
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.96   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.96   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
92.6
sex hormone-binding globulin measurement
6
1
6
70.5
eosinophil count
1
1
1
46.2
sum of eosinophil and basophil counts
1
1
1
39.8
2
1
0
1
34.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
92.6
sex hormone-binding globulin measurement
6
70.5
eosinophil count
1
46.2
sum of eosinophil and basophil counts
1
39.8
0
1
34.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box A3
VGNC:2403
456143
Macaque
forkhead box A3
715663
Mouse
MGI:1347477
15377
Rat
RGD:2809
25100
Dog
forkhead box A3
VGNC:40945
484434
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box A3
Macaque
forkhead box A3
Mouse
Rat
Dog
forkhead box A3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P55318-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (36)
1 – 10 of 36
KHDRBS2
Tbio
Novelty: 0.01986638
p_int: 0.844849749
p_ni: 0.149947018
p_wrong: 0.005203233
Score: 0.189
Data Source: BioPlex,STRINGDB
ST3GAL2
Tbio
Family: Enzyme
Novelty: 0.03503891
p_int: 0.814736638
p_ni: 0.184463894
p_wrong: 0.000799468
Score: 0.316
Data Source: BioPlex,STRINGDB
CORO1A
Tbio
Novelty: 0.00898925
p_int: 0.806124334
p_ni: 0.193875498
p_wrong: 1.68e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
HNF1A
Tbio
Family: TF
Novelty: 0.00101291
Score: 0.944
Data Source: STRINGDB
HNF4A
Tchem
Family: NR
Novelty: 0.00041409
Score: 0.687
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.642
Data Source: STRINGDB
ONECUT1
Tbio
Family: TF
Novelty: 0.0086548
Score: 0.641
Data Source: STRINGDB
SOX17
Tbio
Family: TF
Novelty: 0.00328146
Score: 0.59
Data Source: STRINGDB
SPDEF
Tbio
Family: TF
Novelty: 0.00618802
Score: 0.59
Data Source: STRINGDB
GATA6
Tbio
Family: TF
Novelty: 0.00267511
Score: 0.587
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.96

PubMed score by year
PubTator Score  20.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: